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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 467-476 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We demonstrate theoretically and experimentally how the dipolar field can be used in nuclear magnetic resonance (NMR) to investigate the structure of heterogeneous liquid systems. Using the Fourier transformed dipolar field and magnetization distribution, a simple relation between the NMR signal generated by the dipolar field and the sample structure can be established. On the basis of this relation, theoretical models for periodic structures have been derived and used to analyze the variation of the NMR signal as a function of the spatial modulation imposed on the magnetization. If the spatial modulations imposed on the transverse and longitudinal magnetizations have the same wavelength, the signal generated by the dipolar field is a continuous function of the modulation wavelength and is sensitive to the structure of the sample. When this condition is not met, diffraction phenomena may be possible in periodic structures. To test the theoretical work, experimental data have been obtained from water surrounding randomly packed microspheres. These data are in agreement with the theoretical predictions and show that a resolution of the order of 10 μm can be achieved for highly mobile systems. For spin bearing molecules, whose self-diffusion coefficient is two orders of magnitude less than that of free water, submicrometer resolution is expected. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 702-706 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The long-range nuclear dipolar interactions in liquids are not averaged out by molecular motion and give rise to the dipolar field. In nuclear magnetic resonance experiments, this field can be used to probe the structure of heterogeneous samples. In this contribution, we demonstrate theoretically and experimentally how the signal generated by the dipolar field can provide structural information without the use of any model structure. In the limit where the dipolar field weakly perturbs the evolution of the magnetization, and where the molecular motion is not significantly restricted by the structure, the autocorrelation function, or Patterson function, of the spin density can be obtained. The signal generated by the dipolar field is measured as a function of the spatial modulation imposed on the magnetization and an integral transform of the signal amplitude yields the Patterson function. If the structure is anisotropic, a three-dimensional data set has to be acquired and Fourier transformed. If the sample is isotropic, modulation of the magnetization along a single direction is sufficient and the Patterson function can be calculated from a Hankel transform of the signal amplitude. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 93 (1991), S. 516-532 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 99 (1992), S. 507-524 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 88 (1990), S. 643-651 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 82 (1989), S. 634-639 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 100 (1992), S. 1-17 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 241-245 
    ISSN: 1352-8661
    Keywords: echo-planar imaging ; high magnetic field ; image distortion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract Echo-planar imaging (EPI) is a snapshot technique, which is useful in a wide range of clinical applications, including the study of physiological function. Over recent years, EPI has found a major new use in functional imaging of the brain. Many EPI experiments can benefit from the increased signal-to-noise ratio (S/N) which results from imaging at high magnetic field. Recently, we have built a 3.0-T EPI scanner at Nottingham University. The low-level radiofrequency and control electronics have been constructed in-house. This, coupled with software written specifically for the system, results in a performance and flexibility exceeding that of a commercial system. A quiet head gradient set produces gradients of up to 30 mT m−1. It is driven using a series multiresonant filter circuit, which allows the production of high-strength, trapezoidal- or sinusoidal-switched gradients. Using this scanner it has been possible to obtain images comprising 256×256 pixels, with a 2.5-mm slice and 0.75 mm in-plane resolution, in 140 ms. Multislicing allows a volume set of 16,128×128 images to be obtained in 1.6 s. A comparison of tests performed at fields of 0.5 T and 3.0 T on the same phantom indicates a better than linear increase in S/N with field strength. EPI images obtained at 3.0 T have been used in studies of brain activation during visual stimulation and execution of a simple motor task.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 295-298 
    ISSN: 1352-8661
    Keywords: hyperfast MRI ; EPI MRI ; tagged MRI ; gastric motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract The high speed echo-planar NMR imaging technique is particularly suitable for visualizing human gut motility and transit. To enable a quantitative study of the rheology of the stomach contents, the magnetization can be prepared using a SPAMM (SPAtial Modulation of Magnetization) tagging sequence prior to imaging. Movement of stomach contents has been measured and analyzed temporally and in the Fourier domain and correlated with stomach motility. Increased stomach activity combined with retropulsive motion were observed at about 25 min following a porridge meal, indicating mixing of the meal and inhibition of gastric emptying.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 347-349 
    ISSN: 1352-8661
    Keywords: functional imaging ; EPI ; brain transfer function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract Functional magnetic resonance imaging (fMRI) is becoming an important tool in the mapping of brain activation. However there are two main concerns that need to be answered before functional imaging can be considered truly useful as a neurophysiological tool. The first is that the detected activation may be derived from large veins and, thus, be spatially separate from the underlying brain activity. The second is the incomplete understanding of the brain transfer function and its relation to brain activity, blood flow, and metabolism. This work contains initial results that will help address these points. Models of the brain vasculature predict that signal changes on SE (spin-echo) images are expected to be much smaller in magnitude but very accurate in localizing true areas of activation than on GE (gradient-echo) images which are susceptable to large veins. By comparing activation from SE and GE EPI at 3 T, we have shown that the regions of activation are spatially very similar, suggesting that GE activation is closely linked to the underlying brain activity. We have identified an experimental impulse response of the brain following 8-s visual stimulation. This impulse response can be used to successfully predict the frequency response obtained experimentally and its shape suggests a resonance phenomenon. This suggests the brain transfer function can be modeled from linear response theory corresponding to the inherent feedback control mechanisms of the brain homeostasis. Continuation of this early work will help to identify the links between fMRI signal change and underlying brain physiology.
    Type of Medium: Electronic Resource
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