Publication Date:
2014-05-15
Description:
A concise and efficient route for the synthesis of spiro-pyranopyrazoles and oxa-aza-[3.3.3]propellanes by simple regioselective multicomponent reaction of ninhydrin, malononitrile, hydrazine derivatives, and β -keto esters or dimethyl acetylenedicarboxylate was developed. This protocol provides an alternative method for combinatorial and parallel syntheses in drug discovery. The value of this method lies in its simplicity, regioselectivity, and good yields. The structures of 3 and 4 were corroborated spectroscopically (IR, 1 H- and 13 C-NMR, and EI-MS). A plausible mechanism for this type of reaction is proposed ( Schemes 2 and 3 ).
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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