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  • 1
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    An essential role for LEDGF/p75 in HIV integration (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-09
    Description: Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically suppressed but not eradicated. Participation of cellular proteins in this obligate replication step is poorly understood. We used intensified RNA interference and dominant-negative protein approaches to show that the cellular transcriptional coactivator lens epithelium-derived growth factor (LEDGF)/p75 (p75) is an essential HIV integration cofactor. The mechanism requires both linkages of a molecular tether that p75 forms between integrase and chromatin. Fractionally minute levels of endogenous p75 are sufficient to enable integration, showing that cellular factors that engage HIV after entry may elude identification in less intensive knockdowns. Perturbing the p75-integrase interaction may have therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Llano, Manuel -- Saenz, Dyana T -- Meehan, Anne -- Wongthida, Phonphimon -- Peretz, Mary -- Walker, William H -- Teo, Wulin -- Poeschla, Eric M -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16959972" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/chemistry/genetics/metabolism/*physiology ; CD4-Positive T-Lymphocytes/metabolism/*virology ; Cell Line ; Chromatin/*metabolism ; HIV Integrase/*metabolism ; HIV-1/*physiology ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; RNA Interference ; Recombinant Fusion Proteins/metabolism ; Transcription Factors/chemistry/genetics/metabolism/*physiology ; *Virus Integration ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Analysis of the non-Markov parameter in continuous-time signal processing (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-02-11
    Description: Author(s): J. J. Varghese, P. A. Bellette, K. J. Weegink, A. P. Bradley, and P. A. Meehan The use of statistical complexity metrics has yielded a number of successful methodologies to differentiate and identify signals from complex systems where the underlying dynamics cannot be calculated. The Mori-Zwanzig framework from statistical mechanics forms the basis for the generalized non-Mark... [Phys. Rev. E 89, 022109] Published Mon Feb 10, 2014
    Keywords: Statistical Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterisation of the broiler transport environment and associated physiological consequences
    Amsterdam : Elsevier
    Applied Animal Behaviour Science 26 (1990), S. 291-292 
    Details
    ISSN: 0168-1591
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0168-1591(90)90157-9
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  • 4
    Electronic Resource
    Electronic Resource
    Tracking the civil rights and women's movements in the United States
    Amsterdam : Elsevier
    International Journal of Intercultural Relations 5 (1981), S. 165-173 
    Details
    ISSN: 0147-1767
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Education , Psychology , Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0147-1767(81)90006-7
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  • 5
    Electronic Resource
    Electronic Resource
    Regulation and utilization of microsin promoter turn on in a chromosomal fusion (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 38 (1991), S. 719-726 
    Details
    ISSN: 0006-3592
    Keywords: microsin B17 promoter ; fusion strain ; gene expression ; growth rate dependence ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Prior work has demonstrated that the microsin antibiotics are produced by enteric bacteria when the growth medium is depleted of nutrients. Because the control loci could have biotechnical potential, and general stress-response phenomena are of importance to understanding how bacteria survive in natural and bioreactor environments, we examined further the growth rate dependence of gene expression under the control of the microsin B17 promoter. This work entailed performing batch and chemostat growth experiments with a strain of E. coli K-12 containing a mcbA-lacZ gene fusion in the chromosome. Our results indicate that when a culture is presented with excess respiratory substrate, a well defined growth rate exists, below which a significant induction event occurs. However, cultures that are fermenting or highly glycolytic tend to express poorly. Additionally, the utility of the fusion strain was examined by performing fed-batch cultivation experiments. We found that sustained production in a fed-batch reactor can be accomplished by using a straightforward, exponential nutrient feeding profile.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260380705
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  • 6
    Electronic Resource
    Electronic Resource
    Cultivator for NMR studies of suspended cell cultures (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 40 (1992), S. 1359-1366 
    Details
    ISSN: 0006-3592
    Keywords: NMR studies ; cell cultures ; Saccharomyces cerevisiae ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: When nuclear magnetic resonance (NMR) spectroscopy is employed for physiological experiments with suspended cells, providing for adequate nutrient and oxygen delivery is particularly important, because the inherent insensitivity of NMR requires that concentrated cell suspensions be used. In addition, it is desirable to be able to manipulate the growth rate of cells during a NMR experiment. To address these concerns, a continuous cell cultivator that provides convective oxygen and nutrient transport has been constructed for NMR experiments. The NMR detector coil is located within the cultivator volume. The location is advantageous because the rapid exchange of cells in and out of the coil leads to a small apparent spin lattice relaxation time, thus allowing for rapid pulsing and fast signal averaging. In this article we present the physical principles on which the cultivator's design is based. 31P spectra showing the response of continuously cultivated Saccharomyces cerevisiae cultures to a phosphate bolus and growth rate shift are then given. © 1992 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260401110
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  • 7
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    Focusing management needs at the sub-catchment level via assessments of change in the cover of estuarine vegetation, Port Hacking, NSW, Australia (2004)
    Springer
    Details
    Publication Date: 2004-10-01
    Print ISSN: 0923-4861
    Electronic ISSN: 1572-9834
    Topics: Biology
    Published by Springer
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