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  • 1
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    An essential role for LEDGF/p75 in HIV integration (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-09
    Description: Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically suppressed but not eradicated. Participation of cellular proteins in this obligate replication step is poorly understood. We used intensified RNA interference and dominant-negative protein approaches to show that the cellular transcriptional coactivator lens epithelium-derived growth factor (LEDGF)/p75 (p75) is an essential HIV integration cofactor. The mechanism requires both linkages of a molecular tether that p75 forms between integrase and chromatin. Fractionally minute levels of endogenous p75 are sufficient to enable integration, showing that cellular factors that engage HIV after entry may elude identification in less intensive knockdowns. Perturbing the p75-integrase interaction may have therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Llano, Manuel -- Saenz, Dyana T -- Meehan, Anne -- Wongthida, Phonphimon -- Peretz, Mary -- Walker, William H -- Teo, Wulin -- Poeschla, Eric M -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16959972" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/chemistry/genetics/metabolism/*physiology ; CD4-Positive T-Lymphocytes/metabolism/*virology ; Cell Line ; Chromatin/*metabolism ; HIV Integrase/*metabolism ; HIV-1/*physiology ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; RNA Interference ; Recombinant Fusion Proteins/metabolism ; Transcription Factors/chemistry/genetics/metabolism/*physiology ; *Virus Integration ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    The Solubility Relations of the Isomeric Dihydroxybenzenes (1931)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 35 (1931), S. 3259-3271 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150329a011
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  • 3
    Electronic Resource
    Electronic Resource
    ANALYTICAL CHEMISTRY. (1898)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 20 (1898), S. 121-125 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02074a045
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  • 4
    Electronic Resource
    Electronic Resource
    ANALYTICAL CHEMISTRY. (1899)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 21 (1899), S. 87-90 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02059a017
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  • 5
    Electronic Resource
    Electronic Resource
    When Not to Acidize (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 5 (1967), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Acidizing water wells to increase yield has proved to be an uneconomical method of well development or rehabilitation in some cases where the aquifer permeability was low and normal operating head great, in wells affected by methane gas, or where the practical sustained yield of the aquifer had been exceeded. Illinois studies show that controlled pumping tests before, during and after development are necessary to accurately evaluate the effectiveness of rehabilitation methods employed. Geologic definition of aquifers and records of pumpage and water-level information are invaluable aids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1967.tb01248.x
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  • 6
    Electronic Resource
    Electronic Resource
    Temperature Dependence of Cortisol Binding to Plasma Proteins (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 852-853 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The cortisol-binding characteristics of two pools of normal human plasma have been determined at different temperatures, using ultrafiltration of plasma with precautions against adsorptive loss and ethanol denaturation as described earlier2. The unbound cortisol concentration in plasma water was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217852a0
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  • 7
    Electronic Resource
    Electronic Resource
    Research in Industrial Laboratories (1917)
    [s.l.] : Nature Publishing Group
    Nature 98 (1917), S. 458-461 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Organisation of Industrial Research. IT is generally conceded by those engaged in the direction of industrial research that, in order to be efficient, research laboratories of this type should be as thoroughly equipped as possible. In the case of industrial concerns having a number of plants ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/098458a0
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  • 8
    Electronic Resource
    Electronic Resource
    Binding of Cortisol to Human Albumin (1967)
    [s.l.] : Nature Publishing Group
    Nature 216 (1967), S. 1334-1335 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Albumin was obtained from Calbiochem as recrystal-lized human albumin grade B. It was seen to consist of only one immunological component when reacted in immunoelectrophoresis against anti-human serum (Burroughs Wellcome). Albumin solutions were prepared in 0-07 molar phosphate buffer, pH. 7-4, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2161334a0
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  • 9
    Electronic Resource
    Electronic Resource
    Bestimmung von Phthalsäureestern in wäßrigen Weich-PVC-Extrakten mittels Dünnschicht-Chromatographie (1973)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 267 (1973), S. 127-128 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Phthalsäureestern in Polyvinylchlorid, Weichmachern ; Chromatographie, Dünnschicht ; Spektralphotometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine dünnschicht-chromatographische Methode zur quantitativen Bestimmung von Phthalsäureestern in wäßrigen Weich-PVC-Extrakten wurde entwickelt. Als Lösungsmittel dient Petroläther-Diäthyläther-Eisessig (8∶2∶0,1); die Beschichtung besteht aus 0,2 mm Silicagel mit Fluorescenzzusatz. Nach Auftrennung und Elution erfolgt eine photometrische Auswertung.
    Notes: Abstract A thinlayer chromatographic method for the quantitative determination of phthalic acid esters in aqueous PVC-plastic extracts has been developed. Petroleum ether/diethyl ether/glacial acetic acid (8∶2∶0.1) is used as solvent; the plates are coated with 0.2 mm of silica gel with fluorescent agent. After separation and elution a photometric determination is performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429966
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  • 10
    Electronic Resource
    Electronic Resource
    Neue Flavoenzyme (1971)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 83 (1971), S. 907-907 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19710832274
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