Publication Date:
1998-08-28
Description:
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornberry, N A -- Lazebnik, Y -- New York, N.Y. -- Science. 1998 Aug 28;281(5381):1312-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9721091" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Apoptosis
;
Catalysis
;
Cysteine Endopeptidases/chemistry/*metabolism
;
Cysteine Proteinase Inhibitors/metabolism/pharmacology/therapeutic use
;
Drug Therapy
;
Enzyme Activation
;
Enzyme Precursors/chemistry/metabolism
;
Humans
;
Neoplasms/drug therapy
;
Substrate Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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