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  • 1
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    Crossover from skin mode to proton-neutron mode in E1 excitations of neutron-rich nuclei (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-03-05
    Description: Author(s): H. Nakada, T. Inakura, and H. Sawai The character of the low-energy E 1 excitations is investigated by analyzing transition densities obtained from the RPA calculations in the doubly magic nuclei. We propose a decomposition method of the E 1 excitations into the p n mode (i.e., oscillation between protons and neutrons) and the skin mode ... [Phys. Rev. C 87, 034302] Published Mon Mar 04, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Geologic evidence for two pre-2004 earthquakes during recent centuries near Port Blair, South Andaman Island, India (2011)
    Geological Society of America (GSA)
    Details
    Publication Date: 2011-06-01
    Description: Coastal stratigraphy near Port Blair, Andaman Islands, where the A.D. 2004 Sumatra-Andaman earthquake was accompanied by [~]1 m of subsidence, provides evidence for two prior earthquakes, perhaps both from the past 400 yr. The first of these (event I) is marked by an abrupt mud-over-peat contact best explained by subsidence similar to that in 2004. Event II is evidenced by an overlying chaotic layer composed of mud clasts in a sandy matrix that is connected with feeder dikes. These mud clasts, probably produced by liquefaction, are capped by laminated sand and mud that we ascribe to an event II tsunami. Radiocarbon ages of plant remains in the peat give discordant ages in the range 100 B.C. to A.D. 1950. Event I probably resembled the 2004 Sumatra-Andaman earthquake in that it was accompanied by subsidence (as much as 1 m) but not by strong shaking near Port Blair. If event II was the A.D. 1762 Arakan earthquake, the laminated sand and mud provide the first evidence that this earthquake was associated with a tsunami.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 3
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    Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ colon adenocarcinomas examined were found to have frameshift mutations in a tract of eight deoxyguanosines [(G)8] within BAX, a gene that promotes apoptosis. These mutations were absent in MMP- tumors and were significantly less frequent in (G)8 repeats from other genes. Frameshift mutations were present in both BAX alleles in some MMP+ colon tumor cell lines and in primary tumors. These results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for colorectal carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rampino, N -- Yamamoto, H -- Ionov, Y -- Li, Y -- Sawai, H -- Reed, J C -- Perucho, M -- CA38579/CA/NCI NIH HHS/ -- CA63585/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):967-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Burnham Institute, La Jolla Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020077" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*genetics ; Alleles ; Apoptosis ; Base Sequence ; Colonic Neoplasms/*genetics ; *Frameshift Mutation ; Gene Expression ; *Genes, Tumor Suppressor ; Humans ; Microsatellite Repeats/*genetics ; Molecular Sequence Data ; Mutation ; Phenotype ; Polymerase Chain Reaction ; Proto-Oncogene Proteins/*genetics ; *Proto-Oncogene Proteins c-bcl-2 ; Sequence Deletion ; Tumor Cells, Cultured ; bcl-2-Associated X Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Statin treatment rescues FGFR3 skeletal dysplasia phenotypes (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-09-19
    Description: Gain-of-function mutations in the fibroblast growth factor receptor 3 gene (FGFR3) result in skeletal dysplasias, such as thanatophoric dysplasia and achondroplasia (ACH). The lack of disease models using human cells has hampered the identification of a clinically effective treatment for these diseases. Here we show that statin treatment can rescue patient-specific induced pluripotent stem cell (iPSC) models and a mouse model of FGFR3 skeletal dysplasia. We converted fibroblasts from thanatophoric dysplasia type I (TD1) and ACH patients into iPSCs. The chondrogenic differentiation of TD1 iPSCs and ACH iPSCs resulted in the formation of degraded cartilage. We found that statins could correct the degraded cartilage in both chondrogenically differentiated TD1 and ACH iPSCs. Treatment of ACH model mice with statin led to a significant recovery of bone growth. These results suggest that statins could represent a medical treatment for infants and children with TD1 and ACH.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamashita, Akihiro -- Morioka, Miho -- Kishi, Hiromi -- Kimura, Takeshi -- Yahara, Yasuhito -- Okada, Minoru -- Fujita, Kaori -- Sawai, Hideaki -- Ikegawa, Shiro -- Tsumaki, Noriyuki -- England -- Nature. 2014 Sep 25;513(7519):507-11. doi: 10.1038/nature13775. Epub 2014 Sep 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Induction and Regulation Field, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. ; 1] Cell Induction and Regulation Field, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan [2] Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. ; Department of Obstetrics and Gynecology, Hyogo College of Medicine, Hyogo 663-8501, Japan. ; Laboratory of Bone and Joint Diseases, Center for Integrated Medical Sciences, RIKEN, Tokyo 108-8639, Japan. ; 1] Cell Induction and Regulation Field, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan [2] Japan Science and Technology Agency, CREST, Tokyo 102-0075, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25231866" target="_blank"〉PubMed〈/a〉
    Keywords: Achondroplasia/*drug therapy/genetics/*pathology ; Animals ; Bone Development/drug effects ; Cartilage/cytology/drug effects/pathology ; Cell Differentiation ; Chondrocytes/cytology/pathology ; Disease Models, Animal ; Female ; Fluorobenzenes/administration & dosage/pharmacology/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & ; dosage/pharmacology/*therapeutic use ; Induced Pluripotent Stem Cells/cytology/pathology ; Lovastatin/pharmacology/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Pyrimidines/administration & dosage/pharmacology/therapeutic use ; Receptor, Fibroblast Growth Factor, Type 3/*deficiency/*genetics ; Rosuvastatin Calcium ; Sulfonamides/administration & dosage/pharmacology/therapeutic use ; Thanatophoric Dysplasia/*drug therapy/genetics/*pathology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Extreme waves in the British Virgin Islands during the last centuries before 1500 CE (2017)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2017-04-01
    Description: Extraordinary marine inundation scattered clasts southward on the island of Anegada, 120 km south of the Puerto Rico Trench, sometime between 1200 and 1480 calibrated years (cal yr) CE. Many of these clasts were likely derived from a fringing reef and from the sandy flat that separates the reef from the island’s north shore. The scattered clasts include no fewer than 200 coral boulders, mapped herein for the first time and mainly found hundreds of meters inland. Many of these are complete colonies of the brain coral Diploria strigosa . Other coral species represented include Orbicella (formerly Montastraea ) annularis , Porites astreoides , and Acropora palmata . Associated bioclastic carbonate sand locally contains articulated cobble-size valves of the lucine Codakia orbicularis and entire conch shells of Strombus gigas , mollusks that still inhabit the sandy shallows between the island’s north shore and a fringing reef beyond. Imbricated limestone slabs are clustered near some of the coral boulders. In addition, fields of scattered limestone boulders and cobbles near sea level extend mainly southward from limestone sources as much as 1 km inland. Radiocarbon ages have been obtained from 27 coral clasts, 8 lucine valves, and 3 conch shells. All these additional ages predate 1500 cal yr CE, all but 2 are in the range 1000–1500 cal yr CE, and 16 of 22 brain coral ages cluster in the range 1200–1480 cal yr CE. The event marked by these coral and mollusk clasts likely occurred in the last centuries before Columbus (before 1492 CE). The pre-Columbian deposits surpass Anegada’s previously reported evidence for extreme waves in post-Columbian time. The coarsest of the modern storm deposits consist of coral rubble that lines the north shore and sandy fans on the south shore; neither of these storm deposits extends more than 50 m inland. More extensive overwash, perhaps by the 1755 Lisbon tsunami, is marked primarily by a sheet of sand and shells found mainly below sea level beneath the floors of modern salt ponds. This sheet extends more than 1 km southward from the north shore and dates to the interval 1650–1800 cal yr CE. Unlike the pre-Columbian deposits, it lacks coarse clasts from the reef or reef flat; its shell assemblage is instead dominated by cerithid gastropods that were merely stirred up from a marine pond in the island’s interior. In their inland extent and clustered pre-Columbian ages, the coral clasts and associated deposits suggest extreme waves unrivaled in recent millennia at Anegada. Bioclastic sand coats limestone 4 m above sea level in areas 0.7 and 1.3 km from the north shore. A coral boulder of nearly 1 m 3 is 3 km from the north shore by way of an unvegetated path near sea level. As currently understood, the extreme flooding evidenced by these and other clasts represents either an extraordinary storm or a tsunami of nearby origin. The storm would need to have produced tsunami-like bores similar to those of 2013 Typhoon Haiyan in the Philippines. Normal faults and a thrust fault provide nearby tsunami sources along the eastern Puerto Rico Trench.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 6
    Electronic Resource
    Electronic Resource
    Density-of-states determination of amorphous silicon from space-charge-limited photocurrents (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 558-560 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The density-of-states around midgap g(E) of undoped amorphous silicon (a-Si:H) has been determined by measuring the space-charge-limited photocurrent (SCLPC) of a-Si:H Schottky diodes under blue light (λ=450 nm) illumination. In this novel technique, a single type of photogenerated carrier is utilized as the source of space charge to dispense with highly doped layers required in the conventional space-charge-limited current (SCLC) technique. Conditions for the uniform formation of space charge are discussed and checked by the satisfaction of a scaling law for samples with different thicknesses. The g(E) deduced from the SCLPC is found to be similar to that from the SCLC technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346086
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation of several types of rpc-5-like resins and their use for the separation of oligonucleotides and mononucleotides by high-performance liquid chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 481 (1989), S. 201-210 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)96764-0
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  • 8
    Electronic Resource
    Electronic Resource
    Oxidative α-addition of isonitrile by use of mercuric salts synthesis of urea and urethane
    Amsterdam : Elsevier
    Tetrahedron Letters 13 (1972), S. 4263-4266 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(01)94290-X
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  • 9
    Electronic Resource
    Electronic Resource
    A new type of organomercuric compound from the reaction of isocyanides with mercuric acetate
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 120 (1976), S. 161-169 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0022-328X(00)98022-7
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  • 10
    Electronic Resource
    Electronic Resource
    The reaction of isocyanide-mercuric chloride complexes with amines. Preparation of guanidines
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 94 (1975), S. 333-343 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0022-328X(00)86941-7
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