Publication Date:
1996-11-22
Description:
Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hahne, M -- Rimoldi, D -- Schroter, M -- Romero, P -- Schreier, M -- French, L E -- Schneider, P -- Bornand, T -- Fontana, A -- Lienard, D -- Cerottini, J -- Tschopp, J -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1363-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland. jurg.tschopp@ib.unil.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910274" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD95/biosynthesis/*physiology
;
*Apoptosis
;
Fas Ligand Protein
;
Humans
;
Ligands
;
Lymphocytes, Tumor-Infiltrating/cytology/immunology
;
Melanoma/*immunology/metabolism/pathology/secondary
;
Membrane Glycoproteins/analysis/biosynthesis/*physiology
;
Mice
;
Mice, Inbred C57BL
;
T-Lymphocytes, Cytotoxic/*cytology/immunology
;
Tumor Cells, Cultured
;
*Tumor Escape
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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