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  • 1
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    Decoherence and the fate of an infalling wave packet: Is Alice burning or fuzzing? (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-09-07
    Description: Author(s): Borun D. Chowdhury and Andrea Puhm Recently, Almheiri, Marolf, Polchinski, and Sully have suggested a Gedankenexperiment to test black hole complementarity. They claim that the postulates of black hole complementarity are mutually inconsistent and choose to give up the “absence of drama” for an infalling observer. According to them, ... [Phys. Rev. D 88, 063509] Published Fri Sep 06, 2013
    Keywords: Astrophysics & Cosmology
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Foliation-dependence of CFTs in Lorentzian-AdS/CFT (2016)
    American Physical Society (APS)
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    Publication Date: 2016-02-24
    Description: Author(s): Borun D. Chowdhury and Maulik K. Parikh In the Lorentzian AdS / CFT correspondence, CFTs are identified by asymptotic boundary surfaces and the boundary conditions imposed on those surfaces. However, AdS can be foliated in various ways to give different boundaries. We show that the CFTs obtained using certain distinct foliations are differe… [Phys. Rev. D 93, 046004] Published Tue Feb 23, 2016
    Keywords: String Theory
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Probing the superconducting ground state of the noncentrosymmetric superconductors CaTSi3 (T = Ir, Pt) using muon-spin relaxation and rotation (2014)
    American Physical Society (APS)
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    Publication Date: 2014-09-10
    Description: Author(s): R. P. Singh, A. D. Hillier, D. Chowdhury, J. A. T. Barker, D. McK. Paul, M. R. Lees, and G. Balakrishnan The superconducting properties of CaTSi3 (where T = Pt and Ir) have been investigated using muon spectroscopy. Our muon-spin-relaxation results suggest that in both these superconductors time-reversal symmetry is preserved, while muon-spin-rotation data show that the temperature dependence of the su... [Phys. Rev. B 90, 104504] Published Tue Sep 09, 2014
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin (2014)
    Oxford University Press
    Details
    Publication Date: 2014-10-10
    Description: Tumor metastasis refers to spread of a tumor from site of its origin to distant organs and causes majority of cancer deaths. Although 〉30 metastasis suppressor genes (MSGs) that negatively regulate metastasis have been identified so far, two issues are poorly understood: first, which MSGs oppose metastasis in a tumor type, and second, which molecular function of MSG controls metastasis. Herein, integrative analyses of tumor-transcriptomes ( n = 382), survival data ( n = 530) and lymph node metastases ( n = 100) in lung cancer patients identified non-metastatic 2 (NME2) as a key MSG from a pool of 〉30 metastasis suppressors. Subsequently, we generated a promoter-wide binding map for NME2 using chromatin immunoprecipitation with promoter microarrays (ChIP-chip), and transcriptome profiling. We discovered novel targets of NME2 which are involved in focal adhesion signaling. Importantly, we detected binding of NME2 in promoter of focal adhesion factor, vinculin. Reduced expression of NME2 led to enhanced transcription of vinculin. In comparison, NME1, a close homolog of NME2, did not bind to vinculin promoter nor regulate its expression. In line, enhanced metastasis of NME2-depleted lung cancer cells was found in zebrafish and nude mice tumor models. The metastatic potential of NME2-depleted cells was remarkably diminished upon selective RNA-i-mediated silencing of vinculin. Together, we demonstrate that reduced NME2 levels lead to transcriptional de-repression of vinculin and regulate lung cancer metastasis.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Bulk curves from boundary data in holography (2014)
    American Physical Society (APS)
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    Publication Date: 2014-04-09
    Description: Author(s): Vijay Balasubramanian, Borun D. Chowdhury, Bartłomiej Czech, Jan de Boer, and Michal P. Heller We embed spherical Rindler space—a geometry with a spherical hole in its center—in asymptotically anti– de Sitter (AdS) spacetime and show that it carries a gravitational entropy proportional to the area of the hole. Spherical AdS-Rindler space is holographically dual to an ultraviolet sector of the... [Phys. Rev. D 89, 086004] Published Tue Apr 08, 2014
    Keywords: String Theory
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity (2014)
    Oxford University Press
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    Publication Date: 2014-09-02
    Description: Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding studies involve many TFs, consequently, it is difficult to assign nucleosome reorganization to the binding site occupancy of any particular TF. Therefore, several aspects remain unclear: does TF binding influence nucleosome (re)organizations locally or impact the chromatin landscape at a more global level; are all or only a fraction of TF binding a result of reorganization in nucleosome occupancy and do all TF binding and associated changes in nucleosome occupancy result in altered gene expression? With these in mind, following characterization of two states (before and after induction of a single TF of choice) we determined: (i) genomic binding sites of the TF, (ii) promoter nucleosome occupancy and (iii) transcriptome profiles. Results demonstrated that promoter-proximal TF binding influenced expression of the target gene when it was coupled to nucleosome repositioning at or close to its binding site in most cases. In contrast, only in few cases change in target gene expression was found when TF binding occurred without local nucleosome reorganization.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    DNA breaks and chromosome pulverization from errors in mitosis (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-01-20
    Description: The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei. Whole-chromosome-containing micronuclei form when mitotic errors produce lagging chromosomes. We tracked the fate of newly generated micronuclei and found that they undergo defective and asynchronous DNA replication, resulting in DNA damage and often extensive fragmentation of the chromosome in the micronucleus. Micronuclei can persist in cells over several generations but the chromosome in the micronucleus can also be distributed to daughter nuclei. Thus, chromosome segregation errors potentially lead to mutations and chromosome rearrangements that can integrate into the genome. Pulverization of chromosomes in micronuclei may also be one explanation for 'chromothripsis' in cancer and developmental disorders, where isolated chromosomes or chromosome arms undergo massive local DNA breakage and rearrangement.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271137/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271137/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crasta, Karen -- Ganem, Neil J -- Dagher, Regina -- Lantermann, Alexandra B -- Ivanova, Elena V -- Pan, Yunfeng -- Nezi, Luigi -- Protopopov, Alexei -- Chowdhury, Dipanjan -- Pellman, David -- 1R01CA142698-01/CA/NCI NIH HHS/ -- GM083299/GM/NIGMS NIH HHS/ -- R00 CA154531/CA/NCI NIH HHS/ -- R01 CA142698/CA/NCI NIH HHS/ -- R01 GM083299/GM/NIGMS NIH HHS/ -- R01 GM083299-14/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Jan 18;482(7383):53-8. doi: 10.1038/nature10802.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22258507" target="_blank"〉PubMed〈/a〉
    Keywords: *Aneuploidy ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics/pathology ; *Chromosome Breakage ; Chromosome Segregation ; Comet Assay ; DNA Fragmentation ; DNA Replication ; Humans ; *Micronuclei, Chromosome-Defective ; *Mitosis/genetics ; Neoplasms/etiology/genetics/pathology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Polarization of PAR proteins by advective triggering of a pattern-forming system (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-25
    Description: In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The physical mechanisms by which stable asymmetric PAR distributions arise from transient cortical flows remain unclear. We present evidence that PAR polarity arises from coupling of advective transport by the flowing cell cortex to a multistable PAR reaction-diffusion system. By inducing transient PAR segregation, advection serves as a mechanical trigger for the formation of a PAR pattern within an otherwise stably unpolarized system. We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goehring, Nathan W -- Trong, Philipp Khuc -- Bois, Justin S -- Chowdhury, Debanjan -- Nicola, Ernesto M -- Hyman, Anthony A -- Grill, Stephan W -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1137-41. doi: 10.1126/science.1208619. Epub 2011 Oct 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021673" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*embryology/metabolism ; Caenorhabditis elegans Proteins/genetics/*metabolism ; *Cell Polarity ; Cytoplasm/metabolism ; Diffusion ; Embryo, Nonmammalian/metabolism/*physiology ; Embryonic Development ; Protein Transport
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Heat currents in electronic junctions driven by telegraph noise (2017)
    American Physical Society (APS)
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    Publication Date: 2017-11-29
    Description: Author(s): O. Entin-Wohlman, D. Chowdhury, A. Aharony, and S. Dattagupta The energy and charge fluxes carried by electrons in a two-terminal junction subjected to a random telegraph noise, produced by a single electronic defect, are analyzed. The telegraph processes are imitated by the action of a stochastic electric field that acts on the electrons in the junction. Upon... [Phys. Rev. B 96, 195435] Published Tue Nov 28, 2017
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Towards a holographic realization of the quarkyonic phase (2013)
    American Physical Society (APS)
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    Publication Date: 2013-03-27
    Description: Author(s): Jan de Boer, Borun D. Chowdhury, Michal P. Heller, and Jakub Jankowski Large- N c QCD matter at intermediate baryon density and low temperatures has been conjectured to be in the so-called quarkyonic phase, i.e., to have a quark Fermi surface and on top of it a confined spectrum of excitations. It has been suggested that the presence of the quark Fermi surface leads to a... [Phys. Rev. D 87, 066009] Published Tue Mar 26, 2013
    Keywords: String theory
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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