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  • 1
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    Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-12-05
    Description: Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia. However, the mechanisms underlying cilia formation and function, and in particular the cytoplasmic assembly of dyneins that power ciliary motility, are only poorly understood. Here we report a new gene, kintoun (ktu), involved in this cytoplasmic process. This gene was first identified in a medaka mutant, and found to be mutated in primary ciliary dyskinesia patients from two affected families as well as in the pf13 mutant of Chlamydomonas. In the absence of Ktu/PF13, both outer and inner dynein arms are missing or defective in the axoneme, leading to a loss of motility. Biochemical and immunohistochemical studies show that Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279746/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279746/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Omran, Heymut -- Kobayashi, Daisuke -- Olbrich, Heike -- Tsukahara, Tatsuya -- Loges, Niki T -- Hagiwara, Haruo -- Zhang, Qi -- Leblond, Gerard -- O'Toole, Eileen -- Hara, Chikako -- Mizuno, Hideaki -- Kawano, Hiroyuki -- Fliegauf, Manfred -- Yagi, Toshiki -- Koshida, Sumito -- Miyawaki, Atsushi -- Zentgraf, Hanswalter -- Seithe, Horst -- Reinhardt, Richard -- Watanabe, Yoshinori -- Kamiya, Ritsu -- Mitchell, David R -- Takeda, Hiroyuki -- GM44228/GM/NIGMS NIH HHS/ -- R01 GM044228/GM/NIGMS NIH HHS/ -- R01 GM044228-17/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Dec 4;456(7222):611-6. doi: 10.1038/nature07471.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg Mathildenstrasse 1, D-79106 Freiburg, Germany. heymut.omran@uniklinik-freiburg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19052621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axoneme/chemistry/genetics/*metabolism/pathology ; Chlamydomonas/genetics/metabolism ; Cilia/chemistry/genetics/*metabolism/pathology ; Cloning, Molecular ; Dyneins/*metabolism ; Epithelial Cells/cytology ; Fish Proteins/genetics/*metabolism ; Genes, Recessive/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Kartagener Syndrome/genetics/pathology ; Male ; Mice ; Molecular Sequence Data ; Mutation/genetics ; *Oryzias/embryology/genetics/metabolism ; Protein Binding ; Proteins/genetics/*metabolism ; Sequence Homology, Amino Acid ; Sperm Motility ; Testis/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Great expectations (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyawaki, Atsushi -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):339. doi: 10.1126/science.1182101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Advanced Technology Development Core, RIKEN Brain Science Institute, Saitama, Japan. matsushi@brain.riken.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain/cytology/physiology ; *Diagnostic Techniques, Neurological ; Humans ; *Molecular Probe Techniques ; Neurosciences/*methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-20
    Description: The observation of the regulation of fast protein dynamics in a cellular context requires the development of reliable technologies. Here, a signal regulation cascade reliant on the stimulus-dependent acceleration of the bidirectional flow of mitogen-activated protein kinase (extracellular signal-regulated kinase) across the nuclear envelope was visualized by reversible protein highlighting. Light-induced conversion between the bright and dark states of a monomeric fluorescent protein engineered from a novel coral protein was employed. Because of its photochromic properties, the protein could be highlighted, erased, and highlighted again in a nondestructive manner, allowing direct observation of regulated fast nucleocytoplasmic shuttling of key signaling molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ando, Ryoko -- Mizuno, Hideaki -- Miyawaki, Atsushi -- New York, N.Y. -- Science. 2004 Nov 19;306(5700):1370-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15550670" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Amino Acid Sequence ; Animals ; Anthozoa ; COS Cells ; Cell Nucleus/*metabolism ; Cytoplasm/*metabolism ; Epidermal Growth Factor/pharmacology ; Fluorescence ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Light ; Luminescent Proteins/chemistry/*metabolism ; MAP Kinase Signaling System ; Microscopy, Confocal ; Mitogen-Activated Protein Kinase 3/*metabolism ; Molecular Sequence Data ; Nuclear Envelope/*metabolism ; Phosphorylation ; Protein Transport ; Recombinant Proteins/chemistry/metabolism ; Transfection ; beta Karyopherins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Seeing the machinery of live cells (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsien, R Y -- Miyawaki, A -- NS27177/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jun 19;280(5371):1954-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0647, USA. rtsien@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9669950" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biochemistry/*methods ; *Cell Physiological Phenomena ; Flow Cytometry ; *Fluorescent Dyes ; Gene Expression ; Green Fluorescent Proteins ; *Indicators and Reagents ; *Luminescent Proteins ; Proteins/analysis ; Recombinant Fusion Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Visualization of an endogenous retinoic acid gradient across embryonic development (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-04-09
    Description: In vertebrate development, the body plan is determined by primordial morphogen gradients that suffuse the embryo. Retinoic acid (RA) is an important morphogen involved in patterning the anterior-posterior axis of structures, including the hindbrain and paraxial mesoderm. RA diffuses over long distances, and its activity is spatially restricted by synthesizing and degrading enzymes. However, gradients of endogenous morphogens in live embryos have not been directly observed; indeed, their existence, distribution and requirement for correct patterning remain controversial. Here we report a family of genetically encoded indicators for RA that we have termed GEPRAs (genetically encoded probes for RA). Using the principle of fluorescence resonance energy transfer we engineered the ligand-binding domains of RA receptors to incorporate cyan-emitting and yellow-emitting fluorescent proteins as fluorescence resonance energy transfer donor and acceptor, respectively, for the reliable detection of ambient free RA. We created three GEPRAs with different affinities for RA, enabling the quantitative measurement of physiological RA concentrations. Live imaging of zebrafish embryos at the gastrula and somitogenesis stages revealed a linear concentration gradient of endogenous RA in a two-tailed source-sink arrangement across the embryo. Modelling of the observed linear RA gradient suggests that the rate of RA diffusion exceeds the spatiotemporal dynamics of embryogenesis, resulting in stability to perturbation. Furthermore, we used GEPRAs in combination with genetic and pharmacological perturbations to resolve competing hypotheses on the structure of the RA gradient during hindbrain formation and somitogenesis. Live imaging of endogenous concentration gradients across embryonic development will allow the precise assignment of molecular mechanisms to developmental dynamics and will accelerate the application of approaches based on morphogen gradients to tissue engineering and regenerative medicine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimozono, Satoshi -- Iimura, Tadahiro -- Kitaguchi, Tetsuya -- Higashijima, Shin-Ichi -- Miyawaki, Atsushi -- England -- Nature. 2013 Apr 18;496(7445):363-6. doi: 10.1038/nature12037. Epub 2013 Apr 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23563268" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Body Patterning/physiology ; Embryo, Nonmammalian/embryology/metabolism ; Embryonic Development/*physiology ; Fibroblast Growth Factors/genetics/metabolism ; Fluorescence Resonance Energy Transfer ; Gastrula/embryology/metabolism ; HeLa Cells ; Humans ; Models, Biological ; Molecular Probes/analysis/genetics/metabolism ; Molecular Sequence Data ; Rhombencephalon/embryology/metabolism ; Somites/embryology/metabolism ; Substrate Specificity ; Tretinoin/analysis/*metabolism ; Zebrafish/*embryology/*metabolism ; Zebrafish Proteins/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Local generation of glia is a major astrocyte source in postnatal cortex (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-30
    Description: Glial cells constitute nearly 50% of the cells in the human brain. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity during postnatal development. Because defects in astrocyte generation are associated with severe neurological disorders such as brain tumours, it is important to understand how astrocytes are produced. Astrocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in the subventricular zone, with the contribution from each region shifting with time. During the first three weeks of postnatal development, the glial cell population, which contains predominantly astrocytes, expands 6-8-fold in the rodent brain. Little is known about the mechanisms underlying this expansion. Here we show that a major source of glia in the postnatal cortex in mice is the local proliferation of differentiated astrocytes. Unlike glial progenitors in the subventricular zone, differentiated astrocytes undergo symmetric division, and their progeny integrate functionally into the existing glial network as mature astrocytes that form endfeet with blood vessels, couple electrically to neighbouring astrocytes, and take up glutamate after neuronal activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777276/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777276/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ge, Woo-Ping -- Miyawaki, Atsushi -- Gage, Fred H -- Jan, Yuh Nung -- Jan, Lily Yeh -- 1K99NS073735/NS/NINDS NIH HHS/ -- 4R37MH065334/MH/NIMH NIH HHS/ -- MH090258/MH/NIMH NIH HHS/ -- P01 AG010435/AG/NIA NIH HHS/ -- R01 MH090258/MH/NIMH NIH HHS/ -- R37 MH065334/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Mar 28;484(7394):376-80. doi: 10.1038/nature10959.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 1550 4th Street, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22456708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Astrocytes/*cytology/metabolism/physiology ; Cell Differentiation ; Cell Division ; *Cell Lineage ; Cell Proliferation ; Cerebral Cortex/*cytology ; Glutamic Acid/metabolism ; Mice ; Mice, Transgenic ; Neuroglia/*cytology/metabolism ; Time-Lapse Imaging
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Natural and semi-natural vegetation in Japan (1972)
    In:  Blumea - Biodiversity, Evolution and Biogeography of Plants (0006-5196) vol.20 (1972) nr.2 p.435
    Details
    Publication Date: 2015-03-06
    Description: Studies on the composition of the forests and other vegetation of Japan were initiated by J. Tanaka (1887) in the Meiji Era. According to his introduction his field survey started in 1879 and resulted into a classification of vegetation zones (forest zones), mainly of the lowland, based on physiognomy and dominant species. In later years some other major proposals of the vegetation zonation were made. Honda (1900) distinguished also altitudinal zones, based on his survey on dominance, and provided it with the first vegetation map. Nakano (1942—1943) stressed the physiognomy combined with species composition, sociology, and succession but did not produce a map. Kira (1949) described the forest zones of Japan stressing the climax concept and correlating ecology mostly with temperature; he added a map. Miyawaki (1967) wrote a large book (provided with a map) on the vegetation of Japan in which the climax concept played an important role, as it did in the study by Suzuki (1966a) who partly tried to integrate actual vegetation with climax types, paying great attention to the sociological aspect; he gave also a coloured map. Miyoshi (1903) introduced in Japan the study of plant communities and some years later (1907) the study of ecology, and these two disciplines have been pursued by the research schools of his pupils, Nakano at Tokyo University, Yoshii at Tohoku University, etc. A large number of papers have resulted in these two fields of vegetation study, mainly published in the Botanical Magazine, Tokyo (Botanical Society of Japan, 1887—), Japanese Journal of Botany (Japan Science Council, 1922—), Journal of Japanese Botany (Tsumura Laboratory, 1926—), Acta Phytotaxonomica et Geobotanica (Kyoto University, 1932—), Ecological Review (Tohoku University, 1935—), Bulletin of the Japanese Society of Plant Ecology (Tokyo University, 1941—1943), Physiology and Ecology (Physiol. & Ecol. Publish. Ass., Kyoto, 1947—), Hikobia (Hiroshima University, 1950—), Bulletin of the Society of Plant Ecology (Tohoku University, 1951—1954), Hokuriku Journal of Botany or Journal of Geobotany (Kanazawa University, 1952—), Japanese Journal of Ecology (Ecological Society of Japan, 1954—), etc. Besides the papers in these journals, science reports of universities have contributed to the development of ecological studies in Japan. A historic review of plant ecology in Japan and basic concepts, principles, and methodologies of ecology was given by Numata (1953, revised edition 1967) and a very brief bibliography of the literature concerned was published in ‘Ecology’ (Numata, 1958).
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
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  • 8
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    Natural and semi-natural vegetation in Japan (1972)
    In:  Blumea: Biodiversity, Evolution and Biogeography of Plants vol. 20 no. 2, pp. 435-496
    Details
    Publication Date: 2024-01-12
    Description: Studies on the composition of the forests and other vegetation of Japan were initiated by J. Tanaka (1887) in the Meiji Era. According to his introduction his field survey started in 1879 and resulted into a classification of vegetation zones (forest zones), mainly of the lowland, based on physiognomy and dominant species. In later years some other major proposals of the vegetation zonation were made. Honda (1900) distinguished also altitudinal zones, based on his survey on dominance, and provided it with the first vegetation map. Nakano (1942\xe2\x80\x941943) stressed the physiognomy combined with species composition, sociology, and succession but did not produce a map. Kira (1949) described the forest zones of Japan stressing the climax concept and correlating ecology mostly with temperature; he added a map. Miyawaki (1967) wrote a large book (provided with a map) on the vegetation of Japan in which the climax concept played an important role, as it did in the study by Suzuki (1966a) who partly tried to integrate actual vegetation with climax types, paying great attention to the sociological aspect; he gave also a coloured map. Miyoshi (1903) introduced in Japan the study of plant communities and some years later (1907) the study of ecology, and these two disciplines have been pursued by the research schools of his pupils, Nakano at Tokyo University, Yoshii at Tohoku University, etc. A large number of papers have resulted in these two fields of vegetation study, mainly published in the Botanical Magazine, Tokyo (Botanical Society of Japan, 1887\xe2\x80\x94), Japanese Journal of Botany (Japan Science Council, 1922\xe2\x80\x94), Journal of Japanese Botany (Tsumura Laboratory, 1926\xe2\x80\x94), Acta Phytotaxonomica et Geobotanica (Kyoto University, 1932\xe2\x80\x94), Ecological Review (Tohoku University, 1935\xe2\x80\x94), Bulletin of the Japanese Society of Plant Ecology (Tokyo University, 1941\xe2\x80\x941943), Physiology and Ecology (Physiol. & Ecol. Publish. Ass., Kyoto, 1947\xe2\x80\x94), Hikobia (Hiroshima University, 1950\xe2\x80\x94), Bulletin of the Society of Plant Ecology (Tohoku University, 1951\xe2\x80\x941954), Hokuriku Journal of Botany or Journal of Geobotany (Kanazawa University, 1952\xe2\x80\x94), Japanese Journal of Ecology (Ecological Society of Japan, 1954\xe2\x80\x94), etc.\nBesides the papers in these journals, science reports of universities have contributed to the development of ecological studies in Japan. A historic review of plant ecology in Japan and basic concepts, principles, and methodologies of ecology was given by Numata (1953, revised edition 1967) and a very brief bibliography of the literature concerned was published in \xe2\x80\x98Ecology\xe2\x80\x99 (Numata, 1958).
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 9
    Electronic Resource
    Electronic Resource
    Structure and Function of Inositol 1,4,5-Trisphosphate Receptor (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 707 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb38052.x
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  • 10
    Electronic Resource
    Electronic Resource
    Immunohistochemical Localization of Metabotropic and Ionotropic Glutamate Receptors in the Mouse Brain (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 707 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb38124.x
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