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  • 1
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    Regio- and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-03-31
    Description: Journal of the American Chemical Society DOI: 10.1021/jacs.6b00207
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 2
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    Large reptiles and cold temperatures: Do extreme cold spells set distributional limits for tropical reptiles in Florida? (2016)
    Wiley
    In: Ecosphere
    Details
    Publication Date: 2016-08-18
    Description: Distributional limits of many tropical species in Florida are ultimately determined by tolerance to low temperature. An unprecedented cold spell during 2–11 January 2010, in South Florida provided an opportunity to compare the responses of tropical American crocodiles with warm-temperate American alligators and to compare the responses of nonnative Burmese pythons with native warm-temperate snakes exposed to prolonged cold temperatures. After the January 2010 cold spell, a record number of American crocodiles ( n  = 151) and Burmese pythons ( n  = 36) were found dead. In contrast, no American alligators and no native snakes were found dead. American alligators and American crocodiles behaved differently during the cold spell. American alligators stopped basking and retreated to warmer water. American crocodiles apparently continued to bask during extreme cold temperatures resulting in lethal body temperatures. The mortality of Burmese pythons compared to the absence of mortality for native snakes suggests that the current population of Burmese pythons in the Everglades is less tolerant of cold temperatures than native snakes. Burmese pythons introduced from other parts of their native range may be more tolerant of cold temperatures. We documented the direct effects of cold temperatures on crocodiles and pythons; however, evidence of long-term effects of cold temperature on their populations within their established ranges remains lacking. Mortality of crocodiles and pythons outside of their current established range may be more important in setting distributional limits.
    Electronic ISSN: 2150-8925
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 3
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    metaModules identifies key functional subnetworks in microbiome-related disease (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-01
    Description: Motivation: The human microbiome plays a key role in health and disease. Thanks to comparative metatranscriptomics, the cellular functions that are deregulated by the microbiome in disease can now be computationally explored. Unlike gene-centric approaches, pathway-based methods provide a systemic view of such functions; however, they typically consider each pathway in isolation and in its entirety. They can therefore overlook the key differences that (i) span multiple pathways, (ii) contain bidirectionally deregulated components, (iii) are confined to a pathway region. To capture these properties, computational methods that reach beyond the scope of predefined pathways are needed. Results: By integrating an existing module discovery algorithm into comparative metatranscriptomic analysis, we developed metaModules, a novel computational framework for automated identification of the key functional differences between health- and disease-associated communities. Using this framework, we recovered significantly deregulated subnetworks that were indeed recognized to be involved in two well-studied, microbiome-mediated oral diseases, such as butanoate production in periodontal disease and metabolism of sugar alcohols in dental caries. More importantly, our results indicate that our method can be used for hypothesis generation based on automated discovery of novel, disease-related functional subnetworks, which would otherwise require extensive and laborious manual assessment. Availability and implementation: metaModules is available at https://bitbucket.org/alimay/metamodules/ Contact: a.may@vu.nl or s.abeln@vu.nl Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 4
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    Global-scale similarities in nitrogen release patterns during long-term decomposition (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-01-20
    Description: Litter decomposition provides the primary source of mineral nitrogen (N) for biological activity in most terrestrial ecosystems. A 10-year decomposition experiment in 21 sites from seven biomes found that net N release from leaf litter is dominantly driven by the initial tissue N concentration and mass remaining regardless of climate, edaphic conditions, or biota. Arid grasslands exposed to high ultraviolet radiation were an exception, where net N release was insensitive to initial N. Roots released N linearly with decomposition and exhibited little net N immobilization. We suggest that fundamental constraints on decomposer physiologies lead to predictable global-scale patterns in net N release during decomposition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parton, William -- Silver, Whendee L -- Burke, Ingrid C -- Grassens, Leo -- Harmon, Mark E -- Currie, William S -- King, Jennifer Y -- Adair, E Carol -- Brandt, Leslie A -- Hart, Stephen C -- Fasth, Becky -- New York, N.Y. -- Science. 2007 Jan 19;315(5810):361-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Resource Ecology Laboratory, Colorado State University, 200 West Lake, Campus Mail 1499, Fort Collins, CO 80523-1499, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234944" target="_blank"〉PubMed〈/a〉
    Keywords: *Biodegradation, Environmental ; Carbon/metabolism ; Climate ; *Ecosystem ; Humidity ; Mathematics ; Nitrogen/*metabolism ; Plant Leaves/metabolism ; Plant Roots/metabolism ; Plants/*metabolism ; Poaceae ; Regression Analysis ; Seasons ; Soil Microbiology ; Temperature ; Time Factors ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Neural activity in human hippocampal formation reveals the spatial context of retrieved memories (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-30
    Description: In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Jonathan F -- Neufang, Markus -- Solway, Alec -- Brandt, Armin -- Trippel, Michael -- Mader, Irina -- Hefft, Stefan -- Merkow, Max -- Polyn, Sean M -- Jacobs, Joshua -- Kahana, Michael J -- Schulze-Bonhage, Andreas -- MH-061975/MH/NIMH NIH HHS/ -- R01 MH055687/MH/NIMH NIH HHS/ -- R01 MH061975/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1111-4. doi: 10.1126/science.1244056.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Drexel University, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288336" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Separation ; Electrodes, Implanted ; Epilepsy ; Hippocampus/cytology/*physiology ; Humans ; *Memory, Episodic ; Neurons/*physiology ; Space Perception/*physiology ; Temporal Lobe/cytology/physiology ; User-Computer Interface
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Organic chemistry. Strain-release amination (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-01-28
    Description: To optimize drug candidates, modern medicinal chemists are increasingly turning to an unconventional structural motif: small, strained ring systems. However, the difficulty of introducing substituents such as bicyclo[1.1.1]pentanes, azetidines, or cyclobutanes often outweighs the challenge of synthesizing the parent scaffold itself. Thus, there is an urgent need for general methods to rapidly and directly append such groups onto core scaffolds. Here we report a general strategy to harness the embedded potential energy of effectively spring-loaded C-C and C-N bonds with the most oft-encountered nucleophiles in pharmaceutical chemistry, amines. Strain-release amination can diversify a range of substrates with a multitude of desirable bioisosteres at both the early and late stages of a synthesis. The technique has also been applied to peptide labeling and bioconjugation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730898/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730898/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gianatassio, Ryan -- Lopchuk, Justin M -- Wang, Jie -- Pan, Chung-Mao -- Malins, Lara R -- Prieto, Liher -- Brandt, Thomas A -- Collins, Michael R -- Gallego, Gary M -- Sach, Neal W -- Spangler, Jillian E -- Zhu, Huichin -- Zhu, Jinjiang -- Baran, Phil S -- GM106210/GM/NIGMS NIH HHS/ -- R01 GM106210/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 15;351(6270):241-6. doi: 10.1126/science.aad6252.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. ; Chemical Research and Development, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA. ; Department of Chemistry, La Jolla Laboratories, Pfizer Inc., 10770 Science Center Drive, San Diego, CA 92121, USA. ; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. pbaran@scripps.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26816372" target="_blank"〉PubMed〈/a〉
    Keywords: Amination ; *Chemistry Techniques, Synthetic ; Chemistry, Pharmaceutical ; Peptides/*chemical synthesis ; Pharmaceutical Preparations/*chemical synthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A looming tragedy of the sand commons (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-09-08
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity (2017)
    American Chemical Society (ACS)
    Details
    Publication Date: 2017-02-21
    Description: Journal of the American Chemical Society DOI: 10.1021/jacs.6b13229
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 9
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    Accounting for photodegradation dramatically improves prediction of carbon losses in dryland systems (2017)
    Wiley
    In: Ecosphere
    Details
    Publication Date: 2017-07-29
    Description: Traditional models of decomposition fail to capture litter mass loss patterns in dryland systems. This shortcoming has stimulated research into alternative drivers of decomposition, including photodegradation. Here, we use aboveground litter decomposition data for dryland (arid) sites from the Long-term Intersite Decomposition Experiment Team data set to test hypotheses (models) about the mechanisms and impacts of photodegradation. Incorporating photodegradation into a traditional biotic decomposition model substantially improved model predictions for mass loss at these dryland sites, especially after four years. The best model accounted for the effects of solar radiation via photodegradation loss from the intermediate cellulosic and lignin pools and direct inhibition of microbial decomposition. Despite the concurrent impacts of photodegradation and inhibition on mass loss, the best photodegradation model increased mass loss by an average of 12% per year compared to the biotic-only decomposition model. The best model also allowed soil infiltration into litterbags to reduce photodegradation and inhibition of microbial decomposition by shading litter from solar radiation. Our modeling results did not entirely support the popular hypothesis that initial lignin content increases the effects of photodegradation on litter mass loss; surprisingly, higher initial lignin content decreased the rate of cellulosic photodegradation. Importantly, our results suggest that mass loss rates due to photodegradation may be comparable to biotic decomposition rates: Mass loss due to photodegradation alone resulted in litter mass losses of 6–15% per year, while mass loss due to biotic decomposition ranged from 20% per year during early-stage decomposition to 3% per year during late-stage decomposition. Overall, failing to account for the impacts of solar radiation on litter mass loss under-predicted long-term litter mass loss by approximately 26%. Thus, not including photodegradation in dryland decomposition models likely results in large underestimations of carbon loss from dryland systems.
    Electronic ISSN: 2150-8925
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 10
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    Cardiac atria of BIO 14.6 hamsters are deficient in natriuretic factor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-24
    Description: The hearts of 220-day-old hamsters of the BIO 14.6 strain are deficient in atrial natriuretic factor; saline extracts of atria produce one-third the natriuretic and diuretic effects of extracts of atria from age-matched normal hamsters. BIO 14.6 hamsters are known to develop congestive heart failure with edema when they are about 200 days old, and the venous congestion and edema are preventable by parabiosis with normal hamsters. The humoral mediator, the deficiency of which causes venous congestion and edema in BIO 14.6 hamsters, may be atrial natriuretic factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chimoskey, J E -- Spielman, W S -- Brandt, M A -- Heidemann, S R -- HL01010/HL/NHLBI NIH HHS/ -- HL07404/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):820-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6538050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Cardiomyopathy, Dilated/*physiopathology ; Cricetinae ; Disease Models, Animal ; Heart Failure/*physiopathology ; *Natriuresis ; Natriuretic Agents ; *Protein Deficiency ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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