ISSN:
1432-1327
Keywords:
Key words Electron-transfer reactions
;
DNA
;
Distance dependence
;
Ruthenium complexes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The notion that DNA is capable of electron transfer (ET) has inspired several groups to investigate the nature of this intriguing process. While several factors modulate ET reaction rates, the distance dependence of ET in DNA is the focus of our current investigations. To this end we propose that several design criteria must be met to facilitate the collection of kinetic data corresponding to DNA-mediated ET reactions. These criteria include (1) covalent attachment of site-selective donor-acceptor pairs, (2) incorporation of donor-acceptor pairs that offer minimal structural perturbation of the DNA duplex, and (3) use of spectroscopically distinguishable donor and acceptor complexes that allow identification of kinetic intermediates.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007750050225
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