ISSN:
0021-9304
Keywords:
angiogenesis
;
cell proliferation
;
chitin derivatives
;
cytokine production
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The effects of chitin and its derivatives on the proliferation of human umbilical vein endothelial cells (HUVECs) and on the production of cytokines were examined in vitro. Chitin and its derivatives had no effect on the proliferation of cultured HUVECs. N-Sulfonated 70% deacetylated chitin (S-DAC70) stimulated the production of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α from HUVECs. Compared to S-DAC70, the other materials tested in the present study showed less effect in the stimulation of IL-8 and TNF-α production and had no effect in the stimulation of IL-1β and IL-6 production. These results indicated that S-DAC70 affects HUVECs function but not proliferation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 43: 469-472, 1998
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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