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  • Key words Diacetylenic lipids  (1)
  • Key words Yohimbine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 339-342 
    Details
    ISSN: 1432-1041
    Keywords: Key words Yohimbine ; Salivary secretion ; Anetholtrithi one; tricyclic antidepressants ; α2 adrenoceptor anta gonists ; dry mouth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The present study compares the effects of yohimbine, an alpha2 adrenoceptor antagonist, and anetholtrithione, a reference drug in the treatment of dry mouth, in patients treated with psychotropic drugs (tricyclic antidepressants or neuroleptics) and suffering from xerostomia. Methods: Ten patients were included in a randomized, double-blind, cross-over study, and receiving after yohimbine (3 × 6 mg per day) or anetholtrithione (3 × 25 mg per day) orally for 5 days. Salivary secretion was estimated under resting conditions, before any drug, and then on day 6, 1 h after the ingestion of yohimbine or anetholtrithione. Results: Compared with basal secretion, the increase in salivary flow was significantly more marked after yohimbine than after anetholtrithione. Conclusion: This study demonstrates the sialogenic effect of yohimbine in drug-induced dry mouth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050298
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  • 2
    Electronic Resource
    Electronic Resource
    Anomalous pH dependence of the coexistence pressure of the polymerizable two-chain N-lipid methyl-bis(pentacosadiinoyl-oxyethyl)-amine (1997)
    Springer
    European biophysics journal 26 (1997), S. 271-275 
    Details
    ISSN: 1432-1017
    Keywords: Key words Diacetylenic lipids ; Polymerization ; Microfluorescence ; Filmbalance ; AFM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Molecular films from polymeric materials play an important role in basic research as well as in technology. We have synthesized the double chain diacetylenic ammonium lipid N-bis-(10, 12-pentacosadiinoyl)-oxy-ethyl)-N-methyl-amine (ONCO). We have characterized monomolecular films at the air/water interface by means of microfluorescence filmbalance techniques and by atomic force microscopy (AFM). ONCO forms stable monomolecular films that exhibit a fluid-solid phase transition with a transition enthalpy of 90 kJ/mol at 10 °C and neutral pH. The coexistence pressure was found to decrease with decreasing protonation, which is in contrast to the commonly found Coulomb mechanism. A change in the chain packing due to a different nitrogen bond angle is discussed as a possible mechanism. This model is cor-roborated by the finding that crystals at high and at low pH differ in their polymerization properties as measured by microfluorescence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050080
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