Publication Date:
2007-07-21
Description:
Reduced insulin-like signaling extends the life span of Caenorhabditis elegans and Drosophila. Here, we show that, in mice, less insulin receptor substrate-2 (Irs2) signaling throughout the body or just in the brain extended life span up to 18%. At 22 months of age, brain-specific Irs2 knockout mice were overweight, hyperinsulinemic, and glucose intolerant; however, compared with control mice, they were more active and displayed greater glucose oxidation, and during meals they displayed stable superoxide dismutase-2 concentrations in the hypothalamus. Thus, less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taguchi, Akiko -- Wartschow, Lynn M -- White, Morris F -- DK38712/DK/NIDDK NIH HHS/ -- DK55326/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Jul 20;317(5836):369-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17641201" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Brain/*metabolism
;
Circadian Rhythm
;
Crosses, Genetic
;
Diet
;
Female
;
Glucose/*metabolism
;
*Homeostasis
;
Insulin Receptor Substrate Proteins
;
Insulin Resistance
;
Intracellular Signaling Peptides and Proteins/*metabolism
;
*Longevity
;
Male
;
Mice
;
Mice, Knockout
;
Mice, Transgenic
;
Overweight
;
Oxidation-Reduction
;
Oxygen Consumption
;
Phosphoproteins/*metabolism
;
Respiration
;
*Signal Transduction
;
Superoxide Dismutase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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