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  • 1
    Publication Date: 2008-12-20
    Description: Geochemical models for Mars predict carbonate formation during aqueous alteration. Carbonate-bearing rocks had not previously been detected on Mars' surface, but Mars Reconnaissance Orbiter mapping reveals a regional rock layer with near-infrared spectral characteristics that are consistent with the presence of magnesium carbonate in the Nili Fossae region. The carbonate is closely associated with both phyllosilicate-bearing and olivine-rich rock units and probably formed during the Noachian or early Hesperian era from the alteration of olivine by either hydrothermal fluids or near-surface water. The presence of carbonate as well as accompanying clays suggests that waters were neutral to alkaline at the time of its formation and that acidic weathering, proposed to be characteristic of Hesperian Mars, did not destroy these carbonates and thus did not dominate all aqueous environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehlmann, Bethany L -- Mustard, John F -- Murchie, Scott L -- Poulet, Francois -- Bishop, Janice L -- Brown, Adrian J -- Calvin, Wendy M -- Clark, Roger N -- Marais, David J Des -- Milliken, Ralph E -- Roach, Leah H -- Roush, Ted L -- Swayze, Gregg A -- Wray, James J -- New York, N.Y. -- Science. 2008 Dec 19;322(5909):1828-32. doi: 10.1126/science.1164759.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological Sciences, Brown University, Providence, RI02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19095939" target="_blank"〉PubMed〈/a〉
    Keywords: Extraterrestrial Environment ; Iron Compounds ; *Magnesium ; Magnesium Compounds ; *Mars ; Silicates ; Spacecraft ; Spectrum Analysis ; Temperature ; *Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    ISSN: 1432-1017
    Keywords: Key words Analytical ultracentrifugation ; Biopharmaceutical ; Protein ; Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Analytical ultracentrifugation (AUC) has re-emerged as a powerful technique for protein characterisation. We report the pivotal role sedimentation equilibrium AUC has played in the development of macrophage inflammatory protein-1α (MIP-1α) as a protein therapeutic. MIP-1α has potential clinical applications in cancer but its clinical use is limited, since it associates to form large insoluble aggregates in physiological buffers. Using AUC as a screening technique, we have produced a biologically active variant of MIP-1α, BB-10010, which has a reduced tendency to aggregate in physiological buffers. The aggregation of protein based pharmaceuticals is routinely monitored by size exclusion chromatography (SEC). Comparison of the data acquired by SEC and AUC, demonstrates that owing to the complexity of BB-10010, AUC analysis is required in addition to SEC to provide a rigorous characterisation of molecular association. This work has been extended to include the use of AUC as an analytical tool to monitor the quality of BB-10010 during formulation and stability studies.
    Type of Medium: Electronic Resource
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