Publication Date:
2013-11-30
Description:
In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Jonathan F -- Neufang, Markus -- Solway, Alec -- Brandt, Armin -- Trippel, Michael -- Mader, Irina -- Hefft, Stefan -- Merkow, Max -- Polyn, Sean M -- Jacobs, Joshua -- Kahana, Michael J -- Schulze-Bonhage, Andreas -- MH-061975/MH/NIMH NIH HHS/ -- R01 MH055687/MH/NIMH NIH HHS/ -- R01 MH061975/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1111-4. doi: 10.1126/science.1244056.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Drexel University, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288336" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Separation
;
Electrodes, Implanted
;
Epilepsy
;
Hippocampus/cytology/*physiology
;
Humans
;
*Memory, Episodic
;
Neurons/*physiology
;
Space Perception/*physiology
;
Temporal Lobe/cytology/physiology
;
User-Computer Interface
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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