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  • Springer  (36)
  • American Institute of Physics  (15)
  • American Association for the Advancement of Science  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A crystalline, toxic, peptide metabolite ofTrichoderma spp. isolated from soil (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 294-295 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Isolates ofTrichoderma spp. from pasture soils of Nova Scotia produce at least 7 toxic peptides, probably related to alamethicin, some of which inhibit the growth of cellulase producing rumen bacteria. One of the peptides has been obtained in crystalline form and crystal data on this material is reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964306
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  • 2
    Electronic Resource
    Electronic Resource
    Photosynthesis by carrot tissue cultures (1971)
    Springer
    Planta 102 (1971), S. 11-25 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 14CO2-fixation rates in green carrot callus cultres (about 35 μg chlorophyll/g fresh wt) were determined in gaseous and liquid media using a range of light intensities and CO2 concentrations. Main products of light-dependent CO2-fixation were sucrose, alanine, glutamine, serine/glycine and malic acid. In darkness, glutamine and malic acid were formed. Light CO2-fixation rates were about ten times higher than dark fixation rates and reached 50–90 μmol/mg chlorophyll/h in 10000 lux, 1% CO2 in air. Net O2-evolution by the tissue was demonstrated polarographically under these conditions. Light CO2-fixation rates were linearly related to chlorophyll levels while dark fixation was independent of chlorophyll content. Lowered O2 partial pressures in gaseous conditions increased 14CO2-fixation rates. Ribulose diphosphate carboxylase and phosphoenol pyruvate carboxylase activities and their distribution in subcellular fractions were examined. When carrot tissue cultures were grown for two or four weeks on agar media lacking a carbohydrate source, in 10000 lux and 1% CO2 in either air or N2, dry weight increases were obtained although chlorophyll levels eventually declined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391446
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  • 3
    Electronic Resource
    Electronic Resource
    Sucrose suppression of chlorophyll synthesis in carrot callus cultures (1971)
    Springer
    Planta 98 (1971), S. 150-156 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Substrate levels of sucrose were shown to reduce chlorophyll synthesis in carrot tissue culture strain CRT1 but not in strain CRT2. In CRT1 the effect was shown to be a suppression of greening specifically by sucrose rather than a reducing sugar requirement for chlorophyll synthesis. In CRT1 sucrose caused both a reduction in chloroplast numbers per cell and a suppression of lamellar development in plastids. This effect on chloroplast structure was consistent with the observed reduced photosynthetic efficiency (micromoles CO2 per hour per mg chlorophyll) of CRT1 calluses grown on sucrose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00385347
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  • 4
    Electronic Resource
    Electronic Resource
    Secretion of photosynthetic products by carrot tissue cultures (1971)
    Springer
    Planta 98 (1971), S. 97-108 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Green carrot callus cultures when exposed to 14CO2 in a liquid medium showed ligh-dependent 14C-incorporation into sucrose, glutamine and malic acid. About 5% of total 14C fixed in a 3 h period appeared in these products in the bathing medium; this was not due to tissue damage. Kinetic studies showed that the release occurred from a metabolic and not a storage compartment. The effects of DCMU, temperature and fluoroacetate demonstrated that release from this compartment was under respiratory and not photosynthetic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00385342
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of complement components C3 and C4 by cadralazine and its active metabolite (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 261-265 
    Details
    ISSN: 1432-1041
    Keywords: Cadralazine ; CGP 22639 ; hydralazine ; systemic lupus ; erythematosus ; complement component C4 ; C3 ; drug-induced autoimmunity ; hydroxylamine ; procainamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of the binding of C3 and C4 at concentrations of 19 mmol/l and 15 mmol/l, respectively. Its active metabolite was more potent and inhibited 50% of the C3 and C4 binding at concentrations of 8 and 3.5 mmol/l, respectively. These concentrations are much higher than those found in plasma during therapy. This is consistent with the clinical observation that in patients with normal kidney function cadralazine is not an inducer of SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315206
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  • 6
    Electronic Resource
    Electronic Resource
    High-pressure liquid chromatographic determination of acetylsalicylic acid, salicylic acid, diflunisal, indomethacin, indoprofen and indobufen (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 375-378 
    Details
    ISSN: 1432-1041
    Keywords: acetylsalicylic acid ; diflunisal ; indomethacin ; salicylic acid ; indoprofen ; indobufen ; high-pressure liquid chromatography ; plasma level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A high-pressure liquid chromatographic technique was developed which allowed concurrent measurement of acetylsalicylic acid (ASA) and salicylic acid (SA) in plasma. ASA was extensively deacetylated to SA not only in vivo but also in vitro, even in frozen plasma. The in vitro conversion could be prevented by physostigmine. In vivo, ASA was eliminated within few hours, whereas SA was continuously present following daily administration of conventional doses of ASA. A slight modification of a similar method, originally developed for naproxen determination [9], was found appropriate for measurement of the SA derivative diflunisal, of two non-SA antiinflammatory agents, indomethacin and indoprofen, and of a related anti-platelet agent, indobufen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615408
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  • 7
    Electronic Resource
    Electronic Resource
    Transplacental passage and breast milk concentrations of hydralazine (1982)
    Springer
    European journal of clinical pharmacology 21 (1982), S. 417-419 
    Details
    ISSN: 1432-1041
    Keywords: hydralazine ; pregnancy hypertension ; maternal blood level ; neonatal blood level ; transplacental passage ; breast milk level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The concentrations of “real” and “apparent” (= “real” hydralazine + acid-labile hydrazones) hydralazine in maternal and umbilical plasma obtained at delivery of 6 women treated with hydralazine and atenolol for pregnancy hypertension were measured by gas chromatography. In one of the patients, the concentrations of the same substances were subsequently measured in breast milk. “Apparent” hydralazine reached higher levels in umbilical than in maternal blood. The concentration of “real” hydralazine seemed to be at least as high in the fetus as in the mother. On the other hand, even though the fraction of “real” (i.e. presumably active) hydralazine was greater in milk than in plasma, the total concentration was smaller, and the estimated dose per milk feed of 75ml would not exceed 0.013mg. Thus, hydralazine treatment of the pregnant woman would expose her fetus to effective concentrations of the drug, but breast feeding would not result in a clinically relevant concentration in the infant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542329
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of oral hydralazine in chronic heart failure (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 467-473 
    Details
    ISSN: 1432-1041
    Keywords: hydralazine ; heart failure ; pharmacokinetics ; bioavailability ; metabolism ; hypertension ; dapsone ; acetylator phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of various disease states, other than hypertension, on the pharmacokinetic behaviour of hydralazine is not completely known. In the present study the pharmacokinetics of oral hydralazine has been evaluated in 7 patients with severe, chronic heart failure, using 8 compensated hypertensives as controls. The pharmacokinetics was evaluated by measuring the plasma concentrations of hydralazine (“apparent” and “real” hydralazine) and hydralazine pyruvate hydrazone, and by assessing acetylator phenotype after a small dose of dapsone. The AUC (area under the plasma concentration curve) following a single, oral 50 mg dose was significantly larger in patients with chronic heart failure NYHA Class III–IV than in patients with essential hypertension without cardiac decompensation. A decreased rate of hepatic elimination of hydralazine is suggested as a major contributory factor to this finding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542113
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  • 9
    Electronic Resource
    Electronic Resource
    Acetylator phenotyping: A comparison of the isoniazid and dapsone tests (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 233-234 
    Details
    ISSN: 1432-1041
    Keywords: acetylator phenotyping ; isoniazid ; dapsone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on 5 samples (0–6 h), and by determination of the ratio of monoacetylated (MAD) to unchanged dapsone (DDS) in a single sample obtained 3 h after dapsone intake. In each of 44 subjects examined, there was unequivocal agreement about classification of the subject as a rapid (INH t1/2 〈2 h; MAD/DDS 〉0.3) or slow (INH t1/2 〉2 h; MAD/DDS 〈0.3) acetylator. It appears that the single-sample (3 h) dapsone test is as reliable as the more laborious and time-consuming INH test for acetylator phenotyping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544604
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  • 10
    Electronic Resource
    Electronic Resource
    An optimization framework for feature extraction (1991)
    Springer
    Machine vision and applications 4 (1991), S. 59-87 
    Details
    ISSN: 1432-1769
    Keywords: optimization ; feature extraction ; minimal encoding ; generic models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In this paper, we propose a unified optimization framework for feature extraction that lets us simultaneously take into account image data and semantic knowledge: We model objects using a language that specifies both photometric and geometric constraints and defines an information-theoretic objective function that measures the fit of the models to the data. We then treat the problem of finding objects as one of generating the optimal description of the image in terms of this language. We have validated our framework by performing extensive experiments on detecting objects in aerial imagery described by simple geometric constraints and have developed two algorithms for generating optimal descriptions. The first one starts with a rough sketch of a polygonal object and deforms the initial contour to maximize the objective function, thus finding object outlines. The second one automatically extracts complex rectilinear buildings from complex aerial images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257823
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