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  • 1
    Electronic Resource
    Electronic Resource
    RB-SiC Ceramics Derived from the Phenol Resin Added with Starch (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1144-1147 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Reaction bonded silicon carbide (RB-SiC) was fabricated by phenol resin, starch, solidifiedagent and silicon powder through the following steps: first, carbonizing at high temperature for 7-9h,infiltrating silicon at 1450-1600oC for 0.5-2h, and then removing excessive silicon at 1700oC for 0.5h.Scanning electron microscopy and X-ray diffraction were employed to characterize and analyze themicrostructures and phase composition of the preforms and the final RB-SiC products. In addition, theeffect of carbonization temperature, the amount of starch and solidified agent on strength and apparentporosity of final RB-SiC were also discussed. The results showed that the carbonization process of phenolresin can be divided into three steps: at temperatures from 400oC to 600oC, the structure of polymerchanges less; at temperatures from 600oC to 1000oC, the fundamental chain of polymer is destroyed, andinverts to glass-like carbon; at temperatures from 1000oC to 1200oC, with the increasing of carbonizationtemperature, the structure of glass-like carbon changes into the structure of disorder graphite. And theincreased micro-pores could be obtained by adding starch
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1144.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Fabrication of Fiber-Reinforced CPC Composite Artificial Bone by RP/RT (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 532-533 (Dec. 2006), p. 745-748 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Self-hardening calcium phosphate cement (CPC) could not be used to repair a largesegmental defect in a load-bearing bone because of its brittleness and weak shock resistance as well asultra-minute pores. Recent studies incorporated fibers into CPC to improve its strength. A novelapproach by rapid prototyping and rapid tool technique (RP/RT) was used in this paper to fabricatefibre-reinforced CPC composite artificial bone. The subsequent mechanical experimentsdemonstrated that the compressive strength of the CPC-fiber artificial bone was 24MPa, which wassignificantly higher than 6MPa for CPC control without fiber. And in-vivo experiment about canineradius repair proved that the implanted CPC-fiber artificial bone enabled to provide short-timereinforced mechanical strength, while the degraded fibers created new macropores for new tissueingrowth. In summary, the CPC-fiber artificial bone may facilitate bone ingrowth and its four timesincrease in strength may help extend the use of CPC to larger bone repairs in moderatelystress-bearing locations
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/14/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.532-533.745.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Using of Ethylene Glycol as Pore-Form Agent to Form Interconnected Mesopores in Carbonized Phenol Resin (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 569 (Jan. 2008), p. 265-268 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We used ethylene glycol as pore-forming agent to prepare porous carbon withinterconnected pores derived from phenol–formaldehyde resin. The mixture of resins and glycol wasby polymerization and pyrolysis monolithic material of porous carbon with interconnected mesoporesand a narrow pore size range. The average pore size of the porous carbon obtained was 28.2 nm. Thenitrogen adsorption isotherm for the porous carbon exhibited type IV isotherm, which correspondedto mesoporous adsorption. The method could endow porous carbon with BET surface area and porevolume about 500 m2/g and 0.607 cm3/g, respectively. The mesopores in porous carbon formed as aresult of phase separation of resin-rich phase and glycol-rich phase at polymerization and remove ofglycol-rich at subsequent pyrolysis
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.569.265.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Study on Integrated Method of Medical Implant Manufacture Based on Rapid Prototyping Technology (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 375-376 (Mar. 2008), p. 353-357 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The traditional method to manufacture the medical implant or prosthesis is based onsculpting and on the tissue site,or takes impressions of the entire face about human. The accuracyand efficiency of medical implant or prosthesis produced by conventional method is heavily reliedon the skill and experience of both designer and manufacturer. In this paper, an integrated methodof medical implant manufacture is approached. This integrated strategy was to establish a systemthat allows fabrication of facial prosthesis from digital information, and integrates the rapidprototyping with modeling technology of complex three-dimensional geometry fromhigh-resolution non-invasive imaging, reverse engineering and computer aided design. The researchresults have shown that the integrated method can produce more exact-fit medical implant, that is,the physical model of the implant is more exactly fitted on the skull model. The advantages of thismethod are that the surgeon can plan and rehearse the surgery in advance, and a less invasivesurgical procedure, and less time-consuming reconstructive, and an adequate esthetic can result
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.375-376.353.pdf
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  • 5
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    Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells (2012)
    Wiley
    Details
    Publication Date: 2012-04-16
    Description: The natural phytoestrogen resveratrol (RSV) may have therapeutic potential for arthritic conditions. RSV is chondroprotective for articular cartilage in rabbit models for arthritis, but its biological effects on human articular cartilage and chondrosarcoma cells are unknown. Effects of RSV on human articular cartilage homeostasis were studied by assessing production of matrix-degrading enzymes (MMP-13, ADAMTS-4, and ADAMTS-5), as well as proteoglycan production and synthesis. The counteractions of RSV against catabolic factors (e.g., FGF-2 or IL-1β) were examined by in vitro and ex vivo using monolayer, three-dimensional alginate beads and cartilage explants cultures, respectively. RSV improves cell viability of articular chondrocytes and effectively antagonizes cartilage-degrading protease production that was initiated by catabolic and/or anti-anabolic cytokines in human articular chondrocytes. RSV significantly also enhances BMP7-promoted proteoglycan synthesis as assessed by 35 S-sulfate incorporation. Protein-DNA interaction arrays suggest that RSV inhibits the activation of transcription factors involved in inflammation and cartilage catabolic signaling pathways, including direct downstream regulators of MAPK (e.g., AP-1, PEA3) and NFκB. RSV selectively compromises survival of human chondrosarcoma cells, but not primary articular chondrocytes, revealing cell-specific activity of RSV on non-tumorigenic versus tumor-derived cells. We propose that RSV exerts its chondroprotective functions, in part, by deactivating p53-induced apoptosis in human primary chondrocytes, but not human chondrosarcoma. Our findings suggest that RSV has potential as a unique biologic treatment for both prevention and treatment of cartilage degenerative diseases. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 6
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    Systematic Identification of the Lysine Succinylation in the Protozoan Parasite Toxoplasma gondii (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-11-19
    Description: Journal of Proteome Research DOI: 10.1021/pr500992r
    Print ISSN: 1535-3893
    Electronic ISSN: 1535-3907
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 7
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    Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc (2013)
    Wiley
    Details
    Publication Date: 2013-03-05
    Description: The catabolic cytokine interleukin-1 (IL-1) and endotoxin lipopolysaccharide (LPS) are well-known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL-1 and LPS may potentially be used to slow or prevent disc degeneration in vivo . Here, we elucidate the striking anti-catabolic and anti-inflammatory effects of bovine lactoferricin (LfcinB) in the intervertebral disc (IVD) via antagonism of both IL-1 and LPS-mediated catabolic activity using in vitro and ex vivo analyses. Specifically, we demonstrate the biological counteraction of LfcinB against IL-1 and LPS-mediated proteoglycan (PG) depletion, matrix-degrading enzyme production and enzyme activity in long-term (alginate beads) and short-term (monolayer) culture models using bovine and human nucleus pulposus (NP) cells. LfcinB significantly attenuates the IL-1 and LPS-mediated suppression of PG production and synthesis, and thus restores PG accumulation and pericellular matrix formation. Simultaneously, LfcinB antagonizes catabolic factor mediated induction of multiple cartilage-degrading enzymes, including MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5, in bovine NP cells at both mRNA and protein levels. LfcinB also suppresses the catabolic factor-induced stimulation of oxidative and inflammatory factors such as iNOS, IL-6, and toll-like receptor-2 (TLR-2) and TLR-4. Finally, the ability of LfcinB to antagonize IL-1 and LPS-mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue, suggesting a potential therapeutic benefit of LfcinB on degenerative disc disease in the future. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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