Publication Date:
1993-01-01
Description:
Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-alpha protein was also elevated locally and systemically. Neutralization of TNF-alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotamisligil, G S -- Shargill, N S -- Spiegelman, B M -- DK 42539/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1993 Jan 1;259(5091):87-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7678183" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Adipose Tissue/physiology/*physiopathology
;
Animals
;
Blood Glucose/metabolism
;
Blotting, Northern
;
Diabetes Mellitus, Experimental/physiopathology
;
Glucose Clamp Technique
;
Homeostasis
;
Immunoglobulin G/genetics/pharmacology
;
Insulin/pharmacology
;
Insulin Infusion Systems
;
Insulin Resistance/*genetics
;
Male
;
Mice
;
Mice, Obese
;
Obesity/chemically induced/*genetics/*physiopathology
;
RNA/genetics/isolation & purification
;
RNA, Messenger/*biosynthesis/isolation & purification
;
Rats
;
Rats, Zucker
;
Receptors, Cell Surface/genetics/physiology
;
Receptors, Tumor Necrosis Factor
;
Recombinant Fusion Proteins/pharmacology
;
Reference Values
;
Sodium Glutamate
;
Tumor Necrosis Factor-alpha/biosynthesis/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
