Publication Date:
1983-06-24
Description:
Borna virus replicated persistently in the brains of rats, causing frenzied and apathetic behavioral states in sequence but no mortality. The transient frenzied behavior was caused by an immune-mediated, cytolytic, encephalitic response that was unexpectedly self-limiting. Cessation of active pathological processes coincided with the onset of the passive phase of the disease. This study thus demonstrates suppression of virus-specific inflammation despite continuous viral replication and describes a new mechanism by which chronic encephalitis may become established.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Narayan, O -- Herzog, S -- Frese, K -- Scheefers, H -- Rott, R -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1401-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602380" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Behavior, Animal
;
Borna Disease/immunology/*pathology/psychology
;
Brain/pathology
;
Humans
;
Inflammation/pathology
;
Limbic System/pathology
;
Mice
;
Motor Activity
;
Rats
;
Rats, Inbred Lew
;
T-Lymphocytes/microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
