Publication Date:
1981-04-03
Description:
Polypeptide receptors on mammalian plasma membranes can be categorized on the basis of function. The binding of ligand by class I receptors results in changes in cell metabolism or behavior. Hormone-receptor interactions typify this group. The binding of ligand by class II receptors in ligand internalization. Although changes in cellular activity may result from metabolism of the internalized ligand, the interaction between ligand and class II receptor does not itself lead to alterations in cell behavior. Class II receptors include those for low-density lipoproteins and for alpha-macroglobulin-protease complexes. Although receptors within each category are chemically disparate, they show striking similarities in behavior. Analysis of the behavioral patterns of receptors in each category reveals insights into receptor physiology and allows for a prospective analysis of receptor characteristics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, J -- HL 00598/HL/NHLBI NIH HHS/ -- HL 21120/HL/NHLBI NIH HHS/ -- HL 23376/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):14-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259730" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biological Transport, Active
;
Cations, Divalent/metabolism
;
Humans
;
Ligands
;
Membrane Proteins/*classification/metabolism/physiology
;
Protein Binding
;
Receptors, Cell Surface/classification/metabolism/physiology
;
Receptors, Immunologic/classification/metabolism/physiology
;
Receptors, LDL
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics