Publication Date:
1980-11-14
Description:
Repeated electroconvulsive shock, applied to rats, induces a subsensitivity of dopamine autoreceptors located in the substantia nigra as indexed by single-unit electrophysiological techniques. This reduced sensitivity is time-dependent, since effects similar to those seen with repeated treatment were also observed when single electroconvulsive shock was followed by an appropriate treatment-free interval. These data, coupled with identical results after the repeated administration of tricyclic antidepressants, raise the possibility that a reduction of dopamine autoreceptor sensitivity could underlie both electroconvulsive shock and pharmacological treatment of depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiodo, L A -- Antelman, S M -- 5T32-MH-14634/MH/NIMH NIH HHS/ -- MH-00238/MH/NIMH NIH HHS/ -- MH-32306/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 14;210(4471):799-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254148" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Depression/physiopathology
;
Dopamine/physiology
;
*Electroshock
;
Humans
;
Neurons/physiology
;
Periodicity
;
Rats
;
Receptors, Dopamine/*physiology
;
Substantia Nigra/*physiology
;
Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
