Publication Date:
1989-01-20
Description:
Follicle rupture during ovulation is associated with inflammation-like changes. Because platelet activating factor (PAF) participates in the inflammatory process, the effect of a PAF-specific antagonist, BN52021, on the ovulatory response was tested in rats. BN52021, administered locally, inhibited follicle rupture in rats stimulated to ovulate with human chorionic gonadotropin (hCG). In addition to suppressing rupture of the follicles, this antagonist suppressed the hCG-stimulated increase in ovarian collagenolysis and vascular permeability. The inhibition of ovulation of BN52021 could be reversed by simultaneous administration of PAF. Furthermore, PAF partially reversed the blockage of ovulation by inhibitors of eicosanoid synthesis. Collectively, these results suggest the involvement of PAF in ovulation. Its role seems to be closely related to the metabolism of arachidonic acid. Thus, modulation of PAF action may serve as an additional target for regulation of reproduction via its action on ovulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abisogun, A O -- Braquet, P -- Tsafriri, A -- New York, N.Y. -- Science. 1989 Jan 20;243(4889):381-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2911750" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Capillary Permeability/drug effects
;
Collagen/metabolism
;
*Diterpenes
;
Female
;
Ginkgolides
;
Lactones/pharmacology
;
Ovary/blood supply
;
*Ovulation
;
Platelet Activating Factor/*physiology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
