Publication Date:
1981-07-10
Description:
Measurements were made of the rate of condensation of various monosaccharides with amino groups of hemoglobin to form Schiff base linkages. The reactivity of each sugar was dependent on the extent to which it exists in the open (carbonyl) structure rather than in the ring (hemiacetal or hemiketal) structure. Among the 15 monosaccharides tested, aldoses showed higher reactivities than ketoses. Glucose was the least reactive of the aldohexoses. The emergence of glucose as the primary metabolic fuel may be due in part to the high stability of its ring structure which limits potentially deleterious nonenzymatic glycosylation of proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Higgins, P J -- AM-18223/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):222-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of the Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12192669" target="_blank"〉PubMed〈/a〉
Keywords:
Borohydrides/chemistry
;
*Evolution, Chemical
;
Glucose/chemistry
;
Glycolysis
;
Glycosylation
;
Hemoglobin A/*chemistry
;
Hexoses/chemistry
;
Humans
;
In Vitro Techniques
;
Monosaccharides/*chemistry
;
Schiff Bases/chemical synthesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
