Publication Date:
1999-08-07
Description:
There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyashita-Lin, E M -- Hevner, R -- Wassarman, K M -- Martinez, S -- Rubenstein, J L -- NS34661-01A1/NS/NINDS NIH HHS/ -- R01 MH49428-01/MH/NIMH NIH HHS/ -- R01 MH51561-01A1/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Aug 6;285(5429):906-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0984, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10436162" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/chemistry/*physiology
;
Cadherins/genetics
;
Calbindin 2
;
Carbocyanines
;
DNA-Binding Proteins/genetics
;
Gene Expression
;
Homeodomain Proteins/genetics/physiology
;
Immunohistochemistry
;
In Situ Hybridization
;
Inhibitor of Differentiation Proteins
;
Lymphoid Enhancer-Binding Factor 1
;
Mice
;
Mutation
;
Neocortex/anatomy & histology/*embryology/growth & development/metabolism
;
Nerve Fibers/physiology/ultrastructure
;
Proteins/genetics
;
Receptors, Cell Surface/genetics
;
Receptors, Cytoplasmic and Nuclear/genetics
;
Receptors, Melatonin
;
S100 Calcium Binding Protein G/analysis
;
Steroid 17-alpha-Hydroxylase/analysis
;
Telencephalon/embryology/growth & development/physiology
;
Thalamus/anatomy & histology/*embryology/growth & development/metabolism
;
Transcription Factors/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
