Publication Date:
1999-05-21
Description:
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Covacci, A -- Telford, J L -- Del Giudice, G -- Parsonnet, J -- Rappuoli, R -- New York, N.Y. -- Science. 1999 May 21;284(5418):1328-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334982" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Animals
;
Bacterial Vaccines
;
Biological Evolution
;
Child
;
Genetic Variation
;
Helicobacter Infections/epidemiology/*microbiology/prevention &
;
control/transmission
;
Helicobacter pylori/*genetics/immunology/*pathogenicity
;
Humans
;
Peptic Ulcer/microbiology
;
Stomach/*microbiology
;
Stomach Neoplasms/microbiology
;
Virulence
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
