Publication Date:
2011-05-14
Description:
Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boly, Melanie -- Garrido, Marta Isabel -- Gosseries, Olivia -- Bruno, Marie-Aurelie -- Boveroux, Pierre -- Schnakers, Caroline -- Massimini, Marcello -- Litvak, Vladimir -- Laureys, Steven -- Friston, Karl -- 088130/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2011 May 13;332(6031):858-62. doi: 10.1126/science.1202043.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege and CHU Sart Tilman Hospital, 4000 Liege, Belgium. mboly@ulg.ac.be〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566197" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Aged
;
Aged, 80 and over
;
Auditory Perception
;
Awareness
;
Bayes Theorem
;
Brain Mapping
;
*Consciousness
;
Electroencephalography
;
*Evoked Potentials, Auditory
;
Female
;
Frontal Lobe/physiology/*physiopathology
;
Humans
;
Male
;
Middle Aged
;
Models, Neurological
;
Models, Statistical
;
Neural Pathways
;
Parietal Lobe/physiology/*physiopathology
;
Persistent Vegetative State/diagnosis/*physiopathology
;
Reaction Time
;
Temporal Lobe/physiology/*physiopathology
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
