Publication Date:
2007-04-14
Description:
To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hernandez, Ryan D -- Hubisz, Melissa J -- Wheeler, David A -- Smith, David G -- Ferguson, Betsy -- Rogers, Jeffrey -- Nazareth, Lynne -- Indap, Amit -- Bourquin, Traci -- McPherson, John -- Muzny, Donna -- Gibbs, Richard -- Nielsen, Rasmus -- Bustamante, Carlos D -- 1R01HG003229/HG/NHGRI NIH HHS/ -- NSF0516310/PHS HHS/ -- RR00163/RR/NCRR NIH HHS/ -- RR015383/RR/NCRR NIH HHS/ -- RR05090/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2007 Apr 13;316(5822):240-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17431170" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
China
;
DNA, Mitochondrial
;
Demography
;
Genetics, Medical
;
Humans
;
India
;
*Linkage Disequilibrium
;
Macaca mulatta/*genetics
;
Polymorphism, Single Nucleotide
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
