Publication Date:
2006-01-28
Description:
The transition of DNA secondary structure from an analogous B to Z conformation modulates the dielectric environment of the single-walled carbon nanotube (SWNT) around which it is adsorbed. The SWNT band-gap fluorescence undergoes a red shift when an encapsulating 30-nucleotide oligomer is exposed to counter ions that screen the charged backbone. The transition is thermodynamically identical for DNA on and off the nanotube, except that the propagation length of the former is shorter by five-sixths. The magnitude of the energy shift is described by using an effective medium model and the DNA geometry on the nanotube sidewall. We demonstrate the detection of the B-Z change in whole blood, tissue, and from within living mammalian cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heller, Daniel A -- Jeng, Esther S -- Yeung, Tsun-Kwan -- Martinez, Brittany M -- Moll, Anthonie E -- Gastala, Joseph B -- Strano, Michael S -- New York, N.Y. -- Science. 2006 Jan 27;311(5760):508-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16439657" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Absorption
;
Adsorption
;
Animals
;
Cations, Divalent/chemistry
;
Chickens
;
Circular Dichroism
;
DNA/blood/*chemistry
;
DNA, Z-Form/blood/*chemistry
;
Fluorescence
;
Mathematics
;
Mercury/analysis
;
Mice
;
Models, Molecular
;
Muscle, Skeletal/chemistry
;
*Nanotubes, Carbon
;
*Nucleic Acid Conformation
;
Oligodeoxyribonucleotides/chemistry
;
Spectrometry, Fluorescence
;
Thermodynamics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
