Publication Date:
2016-01-23
Description:
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of proteins that enter the secretory pathway. Environmental insults or increased protein synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or unfolded proteins - known as endoplasmic reticulum stress - and the activation of the adaptive unfolded protein response to restore homeostasis. If protein misfolding is not resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein response help to determine cell fate and function. Furthermore, endoplasmic reticulum stress contributes to the aetiology of many human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Miao -- Kaufman, Randal J -- CA128814/CA/NCI NIH HHS/ -- R01 DK088227/DK/NIDDK NIH HHS/ -- R01 DK103183/DK/NIDDK NIH HHS/ -- R37 DK042394/DK/NIDDK NIH HHS/ -- England -- Nature. 2016 Jan 21;529(7586):326-35. doi: 10.1038/nature17041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26791723" target="_blank"〉PubMed〈/a〉
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
