Publication Date:
2009-02-20
Description:
Nuclear magnetic resonance (NMR) is one of the most versatile experimental methods in chemistry, physics and biology, providing insight into the structure and dynamics of matter at the molecular scale. Its imaging variant-magnetic resonance imaging (MRI)-is widely used to examine the anatomy, physiology and metabolism of the human body. NMR signal detection is traditionally based on Faraday induction in one or multiple radio-frequency resonators that are brought into close proximity with the sample. Alternative principles involving structured-material flux guides, superconducting quantum interference devices, atomic magnetometers, Hall probes or magnetoresistive elements have been explored. However, a common feature of all NMR implementations until now is that they rely on close coupling between the detector and the object under investigation. Here we show that NMR can also be excited and detected by long-range interaction, relying on travelling radio-frequency waves sent and received by an antenna. One benefit of this approach is more uniform coverage of samples that are larger than the wavelength of the NMR signal-an important current issue in MRI of humans at very high magnetic fields. By allowing a significant distance between the probe and the sample, travelling-wave interaction also introduces new possibilities in the design of NMR experiments and systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brunner, David O -- De Zanche, Nicola -- Frohlich, Jurg -- Paska, Jan -- Pruessmann, Klaas P -- England -- Nature. 2009 Feb 19;457(7232):994-8. doi: 10.1038/nature07752.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225521" target="_blank"〉PubMed〈/a〉
Keywords:
Humans
;
Magnetic Resonance Spectroscopy/instrumentation/*methods
;
Phantoms, Imaging
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
