Publication Date:
2008-02-29
Description:
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mizushima, Noboru -- Levine, Beth -- Cuervo, Ana Maria -- Klionsky, Daniel J -- R01 AG021904/AG/NIA NIH HHS/ -- R01 AG021904-06/AG/NIA NIH HHS/ -- R03 AG019834/AG/NIA NIH HHS/ -- R03 AG019834-02/AG/NIA NIH HHS/ -- R21 AG025355/AG/NIA NIH HHS/ -- R21 AG025355-02/AG/NIA NIH HHS/ -- England -- Nature. 2008 Feb 28;451(7182):1069-75. doi: 10.1038/nature06639.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18305538" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/physiology
;
Animals
;
Autophagy/immunology/*physiology
;
Cell Death
;
Cell Survival
;
Humans
;
Immunity, Innate/immunology
;
Neoplasms/pathology
;
Neurodegenerative Diseases/pathology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
