Publication Date:
2014-08-10
Description:
Article Current CRISPR-mediated genome-editing methods are limited by the requirement for a specific +1 nucleotide when using the U6 promoter to drive guide RNA synthesis. Now, Ranganathan et al. report a modification of the CRISPR–Cas9 system that more than doubles the number of targetable CRISPR sites within the human genome. Nature Communications doi: 10.1038/ncomms5516 Authors: Vinod Ranganathan, Karl Wahlin, Julien Maruotti, Donald J. Zack
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics