ALBERT

Description: 〈p〉Publication date: 1 April 2020〈/p〉 〈p〉〈b〉Source:〈/b〉 Applied Surface Science, Volume 508〈/p〉 〈p〉Author(s): Xiao-Jing Ji, Gui-Fang Luan, Ji-Chen Lyu, Lan-Yue Cui, Shuo-Qi Li, Rong-Chang Zeng, Zhen-Lin Wang〈/p〉 〈div xml:lang="en"〉 〈h5〉Abstract〈/h5〉 〈div〉〈p〉Complications related to corrosion and infection of magnesium (Mg) implants are encountered by physical barrier and local drug delivery system. In this work, the multilayer films composed of ciprofloxacin (CIP) and SiO〈sub〉2〈/sub〉 nanoparticles were fabricated on Mg alloys by the spin-spray layer-by-layer assembly method. The resultant films were characterized via FT-IR, XPS, SEM and EDS techniques. The corrosion behaviors of the multilayer films were investigated via electrochemical tests and hydrogen evolution experiment. The obtained films showed corrosion resistance, self-healing ability, antibacterial efficacy and a prolonged release profile. The results also suggested that the loading dosage and the release rate of CIP could be controlled by the assembly parameters. Moreover, the 〈em〉in vitro〈/em〉 release kinetics of CIP from the multilayer films could be fitted with the pseudo-second-order model.〈/p〉〈/div〉 〈/div〉 〈div xml:lang="en"〉 〈h5〉Graphical abstract〈/h5〉 〈div〉 〈p〉The (CIP/PAH/SiO〈sub〉2〈/sub〉/PAH)〈sub〉20〈/sub〉 multilayer film was successfully fabricated on magnesium alloys through the spin-spray layer-by-layer technique with the controlled CIP release, excellent antibacterial activity, favorable corrosion resistance and apparent self-healing ability.〈/p〉 〈p〉〈figure〉〈img src="https://ars.els-cdn.com/content/image/1-s2.0-S0169433219340577-ga1.jpg" width="467" alt="Graphical abstract for this article" title=""〉〈/figure〉〈/p〉 〈/div〉 〈/div〉