Publication Date:
2019
Description:
〈p〉The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identifed molecular networks that reprogram cells to pluripotency, the cellular dynamics of these processes remain poorly understood. Here, by combining cellular barcoding, mathematical modelling, and lineage tracing approaches, we demonstrate that reprogramming dynamics in heterogeneous populations are driven by dominant "elite" clones. Clones arise 〈i〉a priori〈/i〉 from a population of poised mouse embryonic fibroblasts (MEFs) derived from Wnt1-expressing cells that may represent a neural crest population. This work highlights the importance of cellular dynamics in fate programming outcomes and uncovers cell competition as a mechanism by which cells with context-specific eliteness emerge to occupy and dominate the reprogramming niche.〈/p〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Natural Sciences in General