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Travels in time: Assessing the functional complexity of T cells [Commentary] (2012)

Haining, W. N.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-02-01

Description: When the host encounters a pathogen, the ensuing immune response involves a complex set of cellular responses distributed across many different types of cells. In T and B lymphocytes of the adaptive immune system, these responses include irreversible differentiation events that generate functionally specialized subpopulations of cells (1). Understanding how pathogens and vaccines influence the number, type, and efficacy of specific differentiation states in the T-cell compartment is a major goal in immunology. The study by Han et al. in PNAS (2) interrogates the functional response of individual T cells over time using a nanofluidic platform. Their experiments reveal that...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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