Publication Date:
2011-07-26
Description:
This paper demonstrates the use of the multivariate analysis for the quick and easy evaluation of the experimental results from the homogeneity test of two new certified reference materials (CRM) of active pharmaceutical ingredients (API): metronidazole and captopril. The principal component analysis (PCA) and the hierarchical cluster analysis (HCA) indicated that some results from the homogeneity test were statistically different when the concentrations of all API impurities were considered simultaneously. Through the use of these statistical tools, it was possible to reduce the standard uncertainty due to between-bottle (in)homogeneity ( u bb ) and consequently the combined standard uncertainty of the certified reference materials ( u CRM ) with 95% confidence level. Content Type Journal Article Pages 1-6 DOI 10.1007/s00769-011-0807-9 Authors Werickson Fortunato de Carvalho Rocha, National Institute of Metrology, Standardization and Industrial Quality (Inmetro), Chemical Metrology Division (Dquim), Av. Nossa Senhora das Graças, 50, Xerém/RJ, 25250-020 Brazil Raquel Nogueira, National Institute of Metrology, Standardization and Industrial Quality (Inmetro), Chemical Metrology Division (Dquim), Organic Analysis Laboratory (Labor), Av. Nossa Senhora das Graças, 50, Xerém/RJ, 25250-020 Brazil Journal Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement Online ISSN 1432-0517 Print ISSN 0949-1775
Print ISSN:
0949-1775
Electronic ISSN:
1432-0517
Topics:
Chemistry and Pharmacology
