ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The integration of drugs and devices is a growing force in the medical industry. The incorporationof pharmaceutical products not only promises to expand the therapeutic scope of device technologybut to access combination products whose therapeutic value stem equally from both the structuralattributes of the device and the intrinsic therapy of the drug. For example, the orthopedic industry isexploring drug-coated hip, knee and bone reconstruction implants capable of promoting healing asan added therapeutic benefit for device recipients. In this context, the drug is eluted locally, beingtargeted in a specific site of interest, thus offering a convenient strategy to avoid adverse effectscommonly observed for systemic treatments of some diseases, as an additional benefit. In addition,these new technologies are generally well adapted to the development of minimally invasive surgeryfor their implantation.In this context, given the wide use of calcium phosphates (CaPs) and bisphosphonates (BPs) for thetherapy of bone-related affections, there was great interest to investigate the chemistry taking placewhen combining the two systems since: (i) it could provide better insight in the mechanism of BPfixation on bones (ii) such combination could act as efficient BP delivery systems when implantedin bone defects
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.377.99.pdf
