Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Summary The authors report on quality tests for capillary columns, which are carried out in their laboratory since a few years. Besides the known test values such as separation number, polarity, adsorption, film thickness, is the significance of the acidity of a column investigated. The acidic or basic behaviour of a column can be determined with considerable sensitivity by a comparison of the peak areas obtained by analyzing the pair 2,6-dimethylaniline and 2,6-dimethylphenol. These test substances have been selected because they show similar retention characteristics on columns of any polarity, similar deviations from the neutral behaviour, lowest possible tendency to form hydrogen bonds, and practically the same response factors for flame ionization and thermal conductivity detectors. The test procedure is described.
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