ISSN:
1432-0878
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 1. White rats were intoxicated with fifty percent ethyl alcohol. Some received but single, others a series of intoxications. Tissues were prepared according toRegaud's method, as modified byKater. The water content of the livers was calculated. 2. The normal hepatic cells contained free, spherical mitochondria, and very little fat. After a single intoxication, within one hour, the chondriosomes tended to fuse and form beaded filaments; within two and a half hours, rod-shaped and filamentous chondriosomes predominated in number; after twelve hours, free spherical and beaded filamentous mitochondria appeared. 3. After a single intoxication, fat accumulated in the hepatic cells in two and a half hours, and increased after twelve hours. 4. The reactions of the hepatic cells to daily intoxication consisted in a change from free spherical mitochondria of the normal to free spheres of diminished size, or to filamentous chondriosomes. After daily intoxication, fat accumulation in the hepatic cells was abundant. 5. The water content of the liver was greatest in the normal and least in the liver of the daily intoxicated rats. Even rats that received but a single intoxication had a percentage of water in the liver less than in the normal. 6. It is concluded that the mitochondria of the liver cells may be utilized as indicators in response to alcoholic intoxication.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00572287
