ISSN:
1432-0878
Keywords:
Key words FGF-FGF receptors
;
Limb initiation
;
Progress zone activity
;
Hand and foot anomalies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Fibroblast growth factor (FGF) receptors constitute a family of four membrane-spanning tyrosine kinases (FGFR1–4) which serve as high-affinity receptors for 17 growth factors (FGF1–17). To study functions of FGF/ FGFR signals in development, mice that carry mutations in each receptor have been created by gene targeting. Analysis of these mutant mice revealed essential functions of FGF receptors in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. In this review we discuss recent work with FGF receptors to illustrate mechanisms, through which the FGF/FGFR signals specify vertebrate limb initiation, outgrowth and patterning.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004410051264
