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Gene expression by constitutive mutants of coliphage lambda (1972)

Nijkamp, H. J. J. ; Szybalski, W. ; Ohashi, M. ; [et al.]

Springer

Molecular genetics and genomics 114 (1972), S. 80-88

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ISSN: 1617-4623

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Mutations c17 and ri c, which permit constitutive expression of genes O and P and transcriptional activation of λ DNA replication, act as new promoters since they map outside the immunity region and direct rightward transcription in the presence of repressor. In the λc17 P -or λri cP- lysogens, this constitutive transcription is restricted to the O-P region, and is at least one order of magnitude lower than that for an induced λP -lysogen. The operator-constitutive mutants v2 and v1v3 give very low levels of constitutive transcription from the l and r strands, respectively.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00268749

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