ISSN:
1432-119X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Recent improvements both in the staining quality and computer-aided quantitation of silver-stained nucleolar organizer region (AgNOR)-associated proteins offer the possibility to reliably investigate these proteins on routinely processed archival material. This article deals with the historical background, the recent introduction of a standardized quantitation, the clinical relevance, and future perspective for AgNOR evaluation. It is specifically emphasized that AgNOR analysis after both standardized staining and computer-aided quantitation (as recommended by the Committee on AgNOR Quantitation of the European Society of Pathology) is now regarded as the gold standard whenever routinely formalin-fixed and paraffin-embedded material is investigated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004180050031
