ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Using locus- and allele-specific oligonucleotide probes, we have studied the polymorphism of the HLA-DR β III locus within the haplotypes of the DRw52 supertypic group. DNA from a number of homozygous typing cells typed for both Dw and DR was used. The DR β III polymorphisms, DRw52a and DRw52b, do not segregate with Dw typing, or with DR typing, indicating that the determinants responsible for Dw-defined T -cell response and for DR haplotypic recognition are not encoded by the DR β III locus. Hence, we can conclude that these DR specificities are encoded by the other functional DR locus, DR β I, while the DR β III locus encodes only the supertypic product.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00364271