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Effect of exercise on propranolol pharmacokinetics (1990)

Frank, S. ; Somani, S. M. ; Kohnle, M.

Springer

European journal of clinical pharmacology 39 (1990), S. 391-394

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ISSN: 1432-1041

Keywords: propranolol ; beta-blockers ; pharmacokinetics ; exercise

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable. This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00315416

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