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Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease (1987)

Norman, T. ; Chiu, E. ; James, R. H. ; [et al.]

Springer

European journal of clinical pharmacology 32 (1987), S. 583-586

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ISSN: 1432-1041

Keywords: tiapride ; Huntington's disease ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following durg administration with a mean value of 0.92 μg/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02455992

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