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Clinical pharmacokinetics and pharmacodynamics of fazadinium in renal failure (1981)

Bevan, D. R. ; Souza, J. D. ; Rouse, J. M. ; [et al.]

Springer

European journal of clinical pharmacology 20 (1981), S. 293-298

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ISSN: 1432-1041

Keywords: neuromuscular relaxants ; fazadinium ; pharmacokinetics ; renal failure ; neuromuscular transmission

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetic behaviour and neuromuscular blockade produced by the administration of fazadinium bromide at a dose of 1 mg/kg have been studied in seven patients with end-stage renal failure. No significant differences were found in the pharmacokinetic or pharmacodynamic properties when compared with patients with normal renal function. It is suggested that fazadinium may be superior to either d-tubocurarine or pancuronium in providing muscle relaxation for patients with renal failure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00618780

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