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The disposition of four tetracyclines in normal subjects (1976)

Green, R. ; Brown, J. R. ; Calvert, R. T.

Springer

European journal of clinical pharmacology 10 (1976), S. 245-250

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ISSN: 1432-1041

Keywords: Tetracyclines ; half life ; volume of distribution ; renal clearance

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The disposition of minocycline, tetracycline, doxycycline and oxytetracycline was investigated in four male volunteers after multiple dosing. Values for half life, renal clearance and volume of distribution were calculated and corrected for plasma protein binding. Tetracycline and oxytetracycline have a much larger volume of distribution than minocycline and doxycycline but similar half lives. They give higher tissue levels for equivalent plasma levels. Since their cost per unit dose is much lower they should be the tetracyclines of first choice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00558336

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