Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Summary The determination of sulphide, cysteine and thiol-containing drugs by high-speed FIA titrations with chemiluminescent detection is described. Two different redox processes, the reduction of hypochlorite by sulphide or thiol-containing drugs and the oxidation of luminol by hypochlorite, were coupled in the same FIA assembly. Procedures were applied to the determination of cysteine, N-acetylcysteine, N-penicillamine, 2-mercaptopropionyl-glycine and thiouracil in pharmaceuticals.
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