ISSN:
1432-072X
Keywords:
Myxobacteria Stigmatella aurantiaca Aurachin Secondary metabolism 3-Deoxy-d-arabino-heptulosonate-7-phosphate synthases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract. 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthases catalyse the first step of the shikimate pathway. Two unrelated DAHP synthase types have been described in plants and bacteria. Two type II (aroA A2 and aroA A5) and one type I DAHP synthase gene (aroA 001) were identified from the myxobacterium Stigmatella aurantiaca Sg a15. Inactivation of aroA A5 leads to a mutant that is impaired in the biosynthesis of aurachins, which are electron transport inhibitors and contain an anthranilate moiety. Feeding of anthranilic acid to the mutant culture restores production of aurachins. Inactivation of aroA A2 and aroA 001 does not impair production of aurachins or other known secondary metabolites of S. aurantiaca Sg a15.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002030000162